Drugs are bound to various serum proteins in different degrees and only unbound or free
drug is pharmacologically active. Although free drug concentration can be estimated from …

This review provides current information on the use of antigen-binding fragments (Fab) from
cleaved antibodies to treat poisoning with digoxin and other potent, low formula mass …

Autosis is a distinct form of cell death that requires both autophagy genes and the Na+, K+-
ATPase pump. However, the relationship between the autophagy machinery and Na+, K+ …

In the immunoassays, an antibody used as a reagent, detects an analyte (antigen) of
interest. Although the noncovalent bound between analyte and complementary antibody is …

Abstract Background: The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup was
formed to provide recommendations on the use of extracorporeal treatments (ECTR) in …

The low therapeutic index of digoxin necessitates careful monitoring of its serum levels. Most
of digoxin immunoassays suffer from interferences with digoxin-like immunoreactive …

Oleander is an ornamental shrub that grows in the United States, Australia, India, Sri Lanka,
China, and other parts of the world. All parts of the plant are poisonous because the …

Digoxin is a cardioactive drug with a narrow therapeutic range. Therapeutic drug monitoring
is essential in clinical practice for efficacy as well as to avoid digoxin toxicity. Immunoassays …

Anticalins are a class of engineered ligand-binding proteins that are based on the lipocalin
scaffold. The lipocalin protein architecture is characterised by a compact, rigid β-barrel that …

Immunoassays are used for therapeutic drug monitoring (TDM), yet may suffer from cross-
reacting compounds able to bind the assay antibodies in a manner similar to the target …