The metabolic syndrome—otherwise called syndrome X, insulin resistance syndrome,
Reaven syndrome, and “the deadly quartet”—is the name given to the aggregate of clinical …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

The metabolic syndrome is a common metabolic disorder that results from the increasing
prevalence of obesity. The disorder is defined in various ways, but in the near future a new …

Muscle insulin resistance is a key feature of obesity and type 2 diabetes and is strongly
associated with increased intramyocellular lipid content and inflammation. However, the …

Insulin resistance is a hallmark of obesity, diabetes, and cardiovascular diseases, and leads
to many of the abnormalities associated with metabolic syndrome. Our understanding of …

It is now recognized that contracting skeletal muscle may synthesize and release interleukin-
6 (IL-6) into the interstitium as well as into the systemic circulation in response to a bout of …

Over the past few years, evidence has accumulated that the human brain is an insulin-
sensitive organ. Insulin regulates activity in a limited number of specific brain areas that are …

The liberation of energy stores from adipocytes is critical to support survival in times of
energy deficit; however, uncontrolled or chronic lipolysis associated with insulin resistance …

Context An upper body/visceral fat distribution in obesity is closely linked with metabolic
complications, whereas increased lower body fat is independently predictive of reduced …