Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …

Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …

A major cause of the paucity of new starting points for drug discovery is the lack of
interaction between academia and industry. Much of the global resource in biology is …

The prevention of parasite transmission from the human host to the mosquito has been
recognized as a vital tool for malaria eradication campaigns. However, transmission …

The threat of widespread drug resistance to frontline antimalarials has renewed the urgency
for identifying inexpensive chemotherapeutic compounds that are effective against …

Malaria transmission-blocking vaccines (TBVs) are potentially helpful tools for malaria
eradication. The standard membrane-feeding assay (SMFA) is considered one of the “gold …

Malaria remains one of the most important public health problems, causing significant
morbidity and mortality. Malaria is a mosquito borne disease transmitted through an …

Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for
those living in poor or developing countries. Almost one-sixth of the world population is at …

Current first-line treatments for uncomplicated falciparum malaria rapidly clear the asexual
stages of the parasite, but do not fully prevent parasite transmission by mosquitoes. The …

Conversion from asexual proliferation to sexual differentiation initiates the production of the
gametocyte, which is the malaria parasite stage required for human-to-mosquito …