Mechanistic basis of enzyme-targeted drugs
JG Robertson - Biochemistry, 2005 - ACS Publications
Enzymes offer unique opportunities for drug design that are not available to cell surface
receptors, nuclear hormone receptors, ion channels, transporters, and DNA. Here, we …
receptors, nuclear hormone receptors, ion channels, transporters, and DNA. Here, we …
Adverse drug reactions of anticancer drugs derived from natural sources
D Tewari, P Rawat, PK Singh - Food and Chemical Toxicology, 2019 - Elsevier
Cancer, a life threatening disease adversely affects huge population worldwide. Naturally
derived drug discovery has emerged as a potential pathway in search of anticancers …
derived drug discovery has emerged as a potential pathway in search of anticancers …
A marine terpenoid, heteronemin, induces both the apoptosis and ferroptosis of hepatocellular carcinoma cells and involves the ROS and MAPK pathways
Hepatocellular carcinoma (HCC) is a leading cause of death, resulting in over 700 thousand
deaths annually worldwide. Chemotherapy is the primary therapeutic strategy for patients …
deaths annually worldwide. Chemotherapy is the primary therapeutic strategy for patients …
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
C Tse, AR Shoemaker, J Adickes, MG Anderson… - Cancer research, 2008 - AACR
Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is
commonly associated with tumor maintenance, progression, and chemoresistance. We …
commonly associated with tumor maintenance, progression, and chemoresistance. We …
Bambu and its applications in the discovery of active molecules against melanoma
Purpose or objective Melanoma is one of the most dangerous forms of skin cancer and the
discovery of novel drugs is an ongoing effort. Quantitative Structure Activity Relationship …
discovery of novel drugs is an ongoing effort. Quantitative Structure Activity Relationship …
Curcumin in cancer and inflammation: an in-depth exploration of molecular interactions, therapeutic potentials, and the role in disease management
DO Moon - International Journal of Molecular Sciences, 2024 - mdpi.com
This paper delves into the diverse and significant roles of curcumin, a polyphenolic
compound from the Curcuma longa plant, in the context of cancer and inflammatory …
compound from the Curcuma longa plant, in the context of cancer and inflammatory …
Discovery of novel polycyclic heterocyclic derivatives from evodiamine for the potential treatment of triple-negative breast cancer
S Xu, H Yao, Y Qiu, M Zhou, D Li, L Wu… - Journal of Medicinal …, 2021 - ACS Publications
Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and
exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping …
exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping …
Selective topotecan delivery to cancer cells by targeted pH-sensitive mesoporous silica nanoparticles
Topotecan (TOP), a water-soluble derivative of camptothecin, is a potent antitumor agent
that is receiving growing attention for the treatment of several types of cancer. However, one …
that is receiving growing attention for the treatment of several types of cancer. However, one …
[HTML][HTML] High glucose-induced oxidative stress accelerates myogenesis by altering SUMO reactions
X Liu, G Heras, VM Lauschke, J Mi, G Tian… - Experimental Cell …, 2020 - Elsevier
Skeletal muscle preservation is a dynamic process that involves constant repair and
regeneration. However, the regenerative capacity of muscle cells declines in hyperglycemia …
regeneration. However, the regenerative capacity of muscle cells declines in hyperglycemia …
FTY720 inhibits tumor growth and enhances the tumor‐suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway
MH Li, T Hla, F Ferrer - Pediatric blood & cancer, 2013 - Wiley Online Library
Background Neuroblastoma (NB) is the most common extra‐cranial solid tumor in
childhood. Poor outcomes for children with advanced disease underscore the need for novel …
childhood. Poor outcomes for children with advanced disease underscore the need for novel …