Enzymes offer unique opportunities for drug design that are not available to cell surface
receptors, nuclear hormone receptors, ion channels, transporters, and DNA. Here, we …

Cancer, a life threatening disease adversely affects huge population worldwide. Naturally
derived drug discovery has emerged as a potential pathway in search of anticancers …

Hepatocellular carcinoma (HCC) is a leading cause of death, resulting in over 700 thousand
deaths annually worldwide. Chemotherapy is the primary therapeutic strategy for patients …

Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is
commonly associated with tumor maintenance, progression, and chemoresistance. We …

Purpose or objective Melanoma is one of the most dangerous forms of skin cancer and the
discovery of novel drugs is an ongoing effort. Quantitative Structure Activity Relationship …

This paper delves into the diverse and significant roles of curcumin, a polyphenolic
compound from the Curcuma longa plant, in the context of cancer and inflammatory …

Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and
exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping …

Topotecan (TOP), a water-soluble derivative of camptothecin, is a potent antitumor agent
that is receiving growing attention for the treatment of several types of cancer. However, one …

Skeletal muscle preservation is a dynamic process that involves constant repair and
regeneration. However, the regenerative capacity of muscle cells declines in hyperglycemia …

Background Neuroblastoma (NB) is the most common extra‐cranial solid tumor in
childhood. Poor outcomes for children with advanced disease underscore the need for novel …