Single-cell and spatial multimodal technologies have propelled discoveries of the solid
tumor microenvironment (TME) molecular features and their correlation with clinical …

Immune-checkpoint blockade has revolutionized cancer treatment, but some cancers, such
as acute myeloid leukemia (AML), do not respond or develop resistance. A potential mode of …

Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …

Abstract Purpose of Review To examine the epidemiological data on obesity and leukemia;
evaluate the effect of obesity on leukemia outcomes in childhood acute lymphoblastic …

Abstract Analysis of the human hematopoietic progenitor compartment is being transformed
by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by …

Inflammation in the bone marrow (BM) microenvironment is a constitutive component of
leukemogenesis in acute myeloid leukemia (AML). Current evidence suggests that both …

Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune
regulation, inflammation, and tumor surveillance. However, while IFNγ levels were elevated …

Cancer initiation is orchestrated by an interplay between tumor-initiating cells and their
stromal/immune environment. Here, by adapted single-cell RNA sequencing, we decipher …

Myeloid malignancies are devastating hematologic cancers with limited therapeutic options.
Inflammation is emerging as a novel driver of myeloid malignancy, with important …

Chimeric antigen receptors (CARs) equipped with an inhibitory signaling domain (iCARs)
have been proposed as strategy to increase on-tumor specificity of CAR-T cell therapies …