Heterogeneous intracellular pathways and biochemical mechanisms are responsible for
generating the glycoprotein complexes of peptide and major histocompatibility complex that …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

Major histocompatibility complex (MHC) class I glycoproteins bind peptides in the
endoplasmic reticulum after incorporation into the peptide-loading complex, whose core is …

Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …

The mechanisms of HLA-DM-catalyzed peptide exchange remain uncertain. Here we found
that all stages of the interaction of HLA-DM with HLA-DR were dependent on the occupancy …

Recombinant αβ T cell receptors, expressed on T cell membranes, recognize short peptides
presented at the cell surface in complex with MHC molecules. There are two main subsets of …

Distinct CD4+ T cell epitopes have been associated with spontaneous control of HIV-1
replication, but analysis of antigen-dependent factors that influence epitope selection is …

Highlights•Immunodominant epitope processing and selection requires DM, MHC II, and
cathepsins.•Immunodominance is determined by epitope abundance.•Antigens from …

Recent structural characterizations of classical and non‐classical major histocompatibility
complex class II (MHCII) proteins have provided a view into the dynamic nature of the MHCII …