Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β cells of the
endocrine pancreas. Pathogenesis of T1DM is different from that of type 2 diabetes mellitus …

Abnormal shifts in the composition of gut microbiota contribute to the pathogenesis of
metabolic diseases, including obesity and type 2 diabetes (T2DM). The crosstalk between …

Genetic contributions to the cause of type 1 diabetes have been studied for more than 30
years, but only recently, with modern genetic tools, has the importance of seemingly minor …

Wolcott-Rallison syndrome (WRS) is a rare, autosomal recessive disorder characterized by
permanent neonatal or early infancy insulin-dependent diabetes. Epiphyseal dysplasia …

Abstract Wolfram syndrome (WFS; OMIM 222300) is an autosomal recessive
neurodegenerative disorder defined by young-onset non-immune insulin-dependent …

The first and still the only book of its kind, this volume offers a concise introduction to human
genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical …

Mice deficient in programmed cell death 1 (PD-1, Pdcd1), an immunoinhibitory receptor
belonging to the CD28/cytotoxic T lymphocyte-associated antigen-4 family, spontaneously …

Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci
have been the prototypical candidates for genetic susceptibility to infectious disease …

Type 1 diabetes results from the autoimmune destruction of insulin-producing β cells in the
pancreas. Genetic and, as yet undefined, environmental factors act together to precipitate …

The discovery of the association between HLA in the major histocompatibility complex
(MHC) on chromosome 6p21 with type 1 diabetes, but not with type 2 diabetes, suggested …