During the past decade, a growing body of evidence has implied that cancer stem cells
(CSCs) play an important role in the development of gastric cancer (GC). The notion that …

Introduction: A major challenge in transplantation is improving long-term organ transplant
and patient survival. Immunosuppressants protect the transplant organ from alloimmune …

Proteins are the functional output of genes. The proteome is defined as the expressed
protein and peptide complement of a cell, organ, or organism, including all isoforms and …

Metabolomics, or biochemical profiling, is closely integrated with genomics and proteomics.
The metabonome is the complete collection of small molecule metabolites or chemicals (< …

Proteogenomics represents a transformative intersection in nephrology, uniting genomics,
transcriptomics, and proteomics to unravel the molecular intricacies of kidney diseases. This …

TP53 tumor suppressor gene mutations are the most frequent genetic alterations in human
cancer affecting a specific gene (1, 2). TP53 gene encodes p53 protein, involved in …

The increase in progressive kidney disease, rising numbers of patients with end-stage renal
disease, organ shortages for kidney transplants and poor long-term graft survival rates …

代谢产物作为生物体各种病理生理过程的最终产物, 其整体表现能够为深入了解机体生理现象及
病理机制提供丰富而实用的信息[1]. 生命体某一时刻下所有小分子代谢物质的集合称为代谢组 …

In the evolving paradigm of drug development it is a reasonable strategy to avoid and/or
anticipate potential risks in drug development for select drugs by performing in vitro and/or …

NPHS2 mutations are responsible for autosomal recessive familial steroid-resistant
nephrotic syndrome (SRNS) with minor glomerular abnormalities or focal segmental …