Nucleoid-associated proteins shape chromatin structure and transcriptional regulation across the bacterial kingdom

HM Amemiya, J Schroeder, PL Freddolino - Transcription, 2021 - Taylor & Francis
Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

Small prokaryotic DNA-binding proteins protect genome integrity throughout the life cycle

K Molan, D Žgur Bertok - International journal of molecular sciences, 2022 - mdpi.com
Genomes of all organisms are persistently threatened by endogenous and exogenous
assaults. Bacterial mechanisms of genome maintenance must provide protection throughout …

[HTML][HTML] The bacterial nucleoid-associated proteins, HU and Dps, condense DNA into context-dependent biphasic or multiphasic complex coacervates

A Gupta, A Joshi, K Arora, S Mukhopadhyay… - Journal of Biological …, 2023 - ASBMB
The bacterial chromosome, known as its nucleoid, is an amorphous assemblage of globular
nucleoprotein domains. It exists in a state of phase separation from the cell's cytoplasm, as …

The combination of omics strategies to evaluate starter and probiotic strains in the Catharina sour Brazilian-style beer

ME Herkenhoff, C Battistini, AB Praia… - Food Research …, 2023 - Elsevier
Catharina sour, the first internationally recognized Brazilian beer, is characterized by
fermentation with lactic acid bacteria (LAB), which may have probiotic potential, and the …

Interpretable detection of novel human viruses from genome sequencing data

JM Bartoszewicz, A Seidel… - NAR genomics and …, 2021 - academic.oup.com
Viruses evolve extremely quickly, so reliable methods for viral host prediction are necessary
to safeguard biosecurity and biosafety alike. Novel human-infecting viruses are difficult to …

Novel insights into construct toxicity, strain optimization, and primary sequence design for producing recombinant silk fibroin and elastin-like peptide in E. coli

A Connor, C Wigham, Y Bai, M Rai, S Nassif… - Metabolic Engineering …, 2023 - Elsevier
Spider silk proteins (spidroins) are a remarkable class of biomaterials that exhibit a unique
combination of high-value attributes and can be processed into numerous morphologies for …

Nucleosomes and flipons exchange energy to alter chromatin conformation, the readout of genomic information, and cell fate

A Herbert - Bioessays, 2022 - Wiley Online Library
Alternative non‐B‐DNA conformations formed under physiological conditions by sequences
called flipons include left‐handed Z‐DNA, three‐stranded triplexes, and four‐stranded i …

[HTML][HTML] Antimicrobial resistance and mechanisms of epigenetic regulation

X Wang, D Yu, L Chen - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
The rampant use of antibiotics in animal husbandry, farming and clinical disease treatment
has led to a significant issue with pathogen resistance worldwide over the past decades …

Protein acetyltransferases mediate bacterial adaptation to a diverse environment

A Dash, R Modak - Journal of Bacteriology, 2021 - Am Soc Microbiol
Protein lysine acetylation is a conserved posttranslational modification that modulates
several cellular processes. Protein acetylation and its physiological implications in …

Role of the DNA-binding protein pA104R in ASFV genome packaging and as a novel target for vaccine and drug development

AC Urbano, F Ferreira - Vaccines, 2020 - mdpi.com
The recent incursions of African swine fever (ASF), a severe, highly contagious,
transboundary viral disease that affects members of the Suidae family, in Europe and China …