Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However,
the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown …

Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-
stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional …

The centromere performs a universally conserved function, to accurately partition genetic
information upon cell division. Yet, centromeres are among the most rapidly evolving …

Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …

Highlights•Kinetochores, large macromolecular assemblies, link chromosome to spindle
microtubules.•Kinetochores are crucially required for accurate chromosome segregation in …

Recent breakthroughs with synthetic budding yeast chromosomes expedite the creation of
synthetic mammalian chromosomes and genomes. Mammals, unlike budding yeast, depend …

The histone H3 variant CENP-A is a crucial epigenetic marker for centromere specification.
CENP-A forms a characteristic nucleosome and dictates the higher-order configuration of …

The kinetochore plays an essential role in facilitating chromosome segregation during cell
division. This massive protein complex assembles onto the centromere of chromosomes and …