A molecular view of kinetochore assembly and function
A Musacchio, A Desai - Biology, 2017 - mdpi.com
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
The molecular basis for centromere identity and function
KL McKinley, IM Cheeseman - Nature reviews Molecular cell biology, 2016 - nature.com
The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …
meiosis. Although the functional importance of the centromere has been appreciated for …
circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1
Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However,
the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown …
the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown …
The cytoplasmic DNA sensor cGAS promotes mitotic cell death
Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-
stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional …
stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional …
[HTML][HTML] Diverse mechanisms of centromere specification
BG Mellone, D Fachinetti - Current Biology, 2021 - cell.com
The centromere performs a universally conserved function, to accurately partition genetic
information upon cell division. Yet, centromeres are among the most rapidly evolving …
information upon cell division. Yet, centromeres are among the most rapidly evolving …
Chromatin structure meets cryo-EM: dynamic building blocks of the functional architecture
Y Takizawa, H Kurumizaka - Biochimica et Biophysica Acta (BBA)-Gene …, 2022 - Elsevier
Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …
[HTML][HTML] Progress in the structural and functional characterization of kinetochores
Highlights•Kinetochores, large macromolecular assemblies, link chromosome to spindle
microtubules.•Kinetochores are crucially required for accurate chromosome segregation in …
microtubules.•Kinetochores are crucially required for accurate chromosome segregation in …
Human artificial chromosomes that bypass centromeric DNA
GA Logsdon, CW Gambogi, MA Liskovykh, EJ Barrey… - Cell, 2019 - cell.com
Recent breakthroughs with synthetic budding yeast chromosomes expedite the creation of
synthetic mammalian chromosomes and genomes. Mammals, unlike budding yeast, depend …
synthetic mammalian chromosomes and genomes. Mammals, unlike budding yeast, depend …
Cryo-EM structures of centromeric tri-nucleosomes containing a central CENP-A nucleosome
The histone H3 variant CENP-A is a crucial epigenetic marker for centromere specification.
CENP-A forms a characteristic nucleosome and dictates the higher-order configuration of …
CENP-A forms a characteristic nucleosome and dictates the higher-order configuration of …
Kinetochore assembly throughout the cell cycle
AP Navarro, IM Cheeseman - Seminars in cell & developmental biology, 2021 - Elsevier
The kinetochore plays an essential role in facilitating chromosome segregation during cell
division. This massive protein complex assembles onto the centromere of chromosomes and …
division. This massive protein complex assembles onto the centromere of chromosomes and …