Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …
Relative hypercoagulopathy of the SARS-CoV-2 beta and delta variants when compared to the less severe omicron variants is related to TEG parameters, the extent of …
LM Grobbelaar, A Kruger, C Venter… - … in thrombosis and …, 2022 - thieme-connect.com
Earlier variants of SARS-CoV-2 have been associated with hypercoagulability and an
extensive formation of fibrin amyloid microclots, which are considered to contribute to the …
extensive formation of fibrin amyloid microclots, which are considered to contribute to the …
Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury
X Zhang, P Gong, Y Zhao, T Wan, K Yuan, Y Xiong… - …, 2022 - thelancet.com
Background Thrombo-inflammation is an important checkpoint that orchestrates infarct
development in ischemic stroke. However, the underlying mechanism remains largely …
development in ischemic stroke. However, the underlying mechanism remains largely …
TEG®, Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy
GJ Laubscher, PJ Lourens, C Venter, DB Kell… - Journal of clinical …, 2021 - mdpi.com
An important component of severe COVID-19 disease is virus-induced endothelilitis. This
leads to disruption of normal endothelial function, initiating a state of failing normal clotting …
leads to disruption of normal endothelial function, initiating a state of failing normal clotting …
[HTML][HTML] RdRp (RNA-dependent RNA polymerase): A key target providing anti-virals for the management of various viral diseases
With the arrival of the Covid-19 pandemic, anti-viral agents have regained center stage in
the arena of medicine. Out of the various drug targets involved in managing RNA-viral …
the arena of medicine. Out of the various drug targets involved in managing RNA-viral …
Biomechanical activation of blood platelets via adhesion to von Willebrand factor studied with mesoscopic simulations
AV Belyaev, YK Kushchenko - Biomechanics and Modeling in …, 2023 - Springer
Platelet adhesion and activation are essential initial processes of arterial and microvascular
hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The …
hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The …
Molecular analysis of SARS-CoV-2 spike protein-induced endothelial cell permeability and vWF secretion
Y Guo, V Kanamarlapudi - International Journal of Molecular Sciences, 2023 - mdpi.com
Coronavirus disease COVID-19, which is caused by severe acute respiratory syndrome
coronavirus SARS-CoV-2, has become a worldwide pandemic in recent years. In addition to …
coronavirus SARS-CoV-2, has become a worldwide pandemic in recent years. In addition to …
Increased levels of inflammatory molecules in blood of Long COVID patients point to thrombotic endotheliitis
S Turner, CA Naidoo, TJ Usher, A Kruger, C Venter… - medRxiv, 2022 - medrxiv.org
The prevailing hypotheses for the persistent symptoms of Long COVID have been narrowed
down to immune dysregulation and autoantibodies, widespread organ damage, viral …
down to immune dysregulation and autoantibodies, widespread organ damage, viral …
COVID-19 and the Response to Antiplatelet Therapy
T Bolek, M Samoš, J Jurica, L Stančiaková… - Journal of Clinical …, 2023 - mdpi.com
The coronavirus SARS-CoV2 disease (COVID-19) is connected with significant morbidity
and mortality (3.4%), disorders in hemostasis, including coagulopathy, activation of platelets …
and mortality (3.4%), disorders in hemostasis, including coagulopathy, activation of platelets …
A systematic review of thromboembolic complications and outcomes in hospitalised COVID-19 patients
Thromboembolic (TE) complications [myocardial infarction (MI), stroke, deep vein
thrombosis (DVT), and pulmonary embolism (PE)] are common causes of mortality in …
thrombosis (DVT), and pulmonary embolism (PE)] are common causes of mortality in …