Probing lysine posttranslational modifications by unnatural amino acids
MN Maas, JCJ Hintzen, J Mecinović - Chemical Communications, 2022 - pubs.rsc.org
Posttranslational modifications, typically small chemical tags attached on amino acids
following protein biosynthesis, have a profound effect on protein structure and function …
following protein biosynthesis, have a profound effect on protein structure and function …
SETD3 functions beyond histidine methylation
R Gao, H Yang, Y Wang - Life Sciences, 2024 - Elsevier
SETD3 is a member of SET domain-containing proteins. It has been discovered as the first
metazoan protein (actin) histidine methyltransferase. In addition to this well-characterized …
metazoan protein (actin) histidine methyltransferase. In addition to this well-characterized …
Structural and Energetic Origin of Different Product Specificities and Activities for SETD3 and Its Mutants on the Methylation of the β-Actin H73K Peptide: Insights from …
YY Zhao, XL Xu, H Deng, KN Wang… - Journal of Chemical …, 2022 - ACS Publications
The methylation of the lysine residue can affect some fundamental biological processes, and
specific biological effects of the methylations are often related to product specificity of …
specific biological effects of the methylations are often related to product specificity of …
The Role of Trp79 in β‐Actin on Histidine Methyltransferase SETD3 Catalysis
MSQ Al‐Fakhar, N Bilgin, L Moesgaard… - …, 2023 - Wiley Online Library
Nτ‐methylation of His73 in actin by histidine methyltransferase SETD3 plays an important
role in stabilising actin filaments in eukaryotes. Mutations in actin and overexpression of …
role in stabilising actin filaments in eukaryotes. Mutations in actin and overexpression of …
[HTML][HTML] Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
VA Türkmen, JCJ Hintzen, A Tumber… - RSC Chemical …, 2023 - pubs.rsc.org
Non-haem Fe (II) and 2-oxoglutarate (2OG) dependent oxygenases catalyse oxidation of
multiple proteins in organisms ranging from bacteria to humans. We describe studies on the …
multiple proteins in organisms ranging from bacteria to humans. We describe studies on the …