Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Abstract Epithelial-mesenchymal transitions (EMTs), the acquisition of mesenchymal
features from epithelial cells, occur during some biological processes and are classified into …

FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in
human cancers,,,–. However, the role and the molecular mechanisms by which FAT1 …

Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch
between collective and single-cell dissemination, controlled by cadherin-mediated cell–cell …

Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-
dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron …

In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour
stemness, metastasis and resistance to therapy. It has recently been proposed that, rather …

Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …

The diverse malignant, stromal, and immune cells in tumors affect growth, metastasis, and
response to therapy. We profiled transcriptomes of∼ 6,000 single cells from 18 head and …

The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an
important role in both development and cancer progression. Depending on the contextual …

Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …