Fecal transplantation for treatment of inflammatory bowel disease

A Imdad, NG Pandit, M Zaman… - Cochrane Database …, 2023 - cochranelibrary.com
Background Inflammatory bowel disease (IBD) is a chronic, relapsing disease of the
gastrointestinal (GI) tract that is thought to be associated with a complex interplay between …

Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection

A Yadegar, S Pakpoor, FF Ibrahim, A Nabavi-Rad… - Cell host & …, 2023 - cell.com
Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent
Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical …

[HTML][HTML] Efficacy and safety of RBX2660 in PUNCH CD3, a phase III, randomized, double-blind, placebo-controlled trial with a Bayesian primary analysis for the …

S Khanna, M Assi, C Lee, D Yoho, T Louie, W Knapple… - Drugs, 2022 - Springer
Abstract Background Recurrent Clostridioides difficile infection, associated with dysbiosis of
gut microbiota, has substantial disease burden in the USA. RBX2660 is a live biotherapeutic …

VE303, a defined bacterial consortium, for prevention of recurrent Clostridioides difficile infection: a randomized clinical trial

T Louie, Y Golan, S Khanna, D Bobilev, N Erpelding… - Jama, 2023 - jamanetwork.com
Importance The effect of rationally defined nonpathogenic, nontoxigenic, commensal strains
of Clostridia on prevention ofClostridioides difficileinfection (CDI) is unknown. Objective To …

A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American …

JM Miller, MJ Binnicker, S Campbell… - Clinical Infectious …, 2018 - academic.oup.com
The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a
close, positive working relationship between the physician/advanced practice provider and …

Safety and tolerability of SER-109 as an investigational microbiome therapeutic in adults with recurrent Clostridioides difficile infection: a phase 3, open-label, single …

MD Sims, S Khanna, P Feuerstadt, TJ Louie… - JAMA Network …, 2023 - jamanetwork.com
Importance A safe and effective treatment for recurrentClostridioides difficileinfection (CDI) is
urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted …

[HTML][HTML] Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy

B Tang, L Tang, S Li, S Liu, J He, P Li, S Wang… - Nature …, 2023 - nature.com
Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is
characterized by increased serum bile acid and adverse fetal outcomes. The aetiology and …

Safety of fecal microbiota, live-jslm (REBYOTA) in individuals with recurrent Clostridioides difficile infection: data from five prospective clinical trials

C Lee, T Louie, L Bancke… - Therapeutic …, 2023 - journals.sagepub.com
Background: Microbiota-based treatments reduce the incidence of recurrent Clostridioides
difficile infections (rCDIs), but prospectively collected safety data needed to broaden patient …

Clostridioides difficile infection in children: Recent updates on epidemiology, diagnosis, therapy

DA Shirley, W Tornel, CA Warren, S Moonah - Pediatrics, 2023 - publications.aap.org
Clostridioides (formerly Clostridium) difficile is the most important infectious cause of
antibiotic-associated diarrhea worldwide and a leading cause of healthcare-associated …

The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection

AM Seekatz, N Safdar… - Therapeutic Advances in …, 2022 - journals.sagepub.com
The species composition of the human gut microbiota is related to overall health, and a
healthy gut microbiome is crucial in maintaining colonization resistance against pathogens …