Radiotherapy and the immune system: More than just immune suppression
Radiotherapy (RT) is still one of the standard cancer therapies, with up to two third of all
cancer patients with solid tumors being irradiated in the course of their disease. The aim of …
cancer patients with solid tumors being irradiated in the course of their disease. The aim of …
The abscopal effect of radiation therapy
DJ Craig, NS Nanavaty, M Devanaboyina… - Future …, 2021 - Taylor & Francis
Radiation therapy (RT) in some cases results in a systemic anticancer response known as
the abscopal effect. Multiple hypotheses support the role of immune activation initiated by …
the abscopal effect. Multiple hypotheses support the role of immune activation initiated by …
Radiotherapy–immunotherapy combinations–perspectives and challenges
Ionizing radiation has historically been used to treat cancer by killing tumour cells, in
particular by inducing DNA damage. This view of radiotherapy (RT) as a simple cytotoxic …
particular by inducing DNA damage. This view of radiotherapy (RT) as a simple cytotoxic …
Hypoxia in solid tumors: how low oxygenation impacts the “Six Rs” of radiotherapy
Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …
Biological mechanisms to reduce radioresistance and increase the efficacy of radiotherapy: state of the art
F Busato, BE Khouzai, M Mognato - International journal of molecular …, 2022 - mdpi.com
Cancer treatment with ionizing radiation (IR) is a well-established and effective clinical
method to fight different types of tumors and is a palliative treatment to cure metastatic …
method to fight different types of tumors and is a palliative treatment to cure metastatic …
[HTML][HTML] A review of the abscopal effect in the era of immunotherapy
E Nabrinsky, J Macklis, J Bitran - Cureus, 2022 - ncbi.nlm.nih.gov
The abscopal effect is a systemic immune response mediated by the effects of radiation on
the immune system. This effect has been observed in a number of cancer types in addition to …
the immune system. This effect has been observed in a number of cancer types in addition to …
[HTML][HTML] Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system
Radiotherapy is a primary therapeutic modality widely utilized with curative intent.
Traditionally tumor response was hypothesized to be due to high levels of cell death …
Traditionally tumor response was hypothesized to be due to high levels of cell death …
Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders
A Vaiserman, JM Cuttler, Y Socol - Biogerontology, 2021 - Springer
Hormesis is any kind of biphasic dose-response when low doses of some agents are
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …
Emerging immunotherapy for acute myeloid leukemia
R Tabata, SG Chi, J Yuda, Y Minami - International Journal of Molecular …, 2021 - mdpi.com
Several immune checkpoint molecules and immune targets in leukemic cells have been
investigated. Recent studies have suggested the potential clinical benefits of immuno …
investigated. Recent studies have suggested the potential clinical benefits of immuno …
[HTML][HTML] Real-world efficacy of anti-PD-1 antibody or combined anti-PD-1 plus anti-CTLA-4 antibodies, with or without radiotherapy, in advanced mucosal melanoma …
Y Umeda, S Yoshikawa, Y Kiniwa, T Maekawa… - European Journal of …, 2021 - Elsevier
Abstract Background Immune checkpoint inhibitors (ICIs) have a lower efficacy in mucosal
melanoma (MUM) than in cutaneous melanoma. The use of combination treatments with …
melanoma (MUM) than in cutaneous melanoma. The use of combination treatments with …