Long non-coding RNAs and rheumatoid arthritis: pathogenesis and clinical implications

O Elazazy, HM Midan, RK Shahin, AE Elesawy… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) are a class of noncoding RNAs with a length larger than
200 nucleotides that participate in various diseases and biological processes as they can …

The small peptide world in long noncoding RNAs

SW Choi, HW Kim, JW Nam - Briefings in bioinformatics, 2019 - academic.oup.com
Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200
nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel …

[HTML][HTML] PTEN/PTENP1:'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy

N Haddadi, Y Lin, G Travis, AM Simpson, NT Nassif… - Molecular cancer, 2018 - Springer
Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …

Long non‐coding RNAs in development and disease: conservation to mechanisms

I Tsagakis, K Douka, I Birds… - The Journal of …, 2020 - Wiley Online Library
Our genomes contain the blueprint of what makes us human and many indications as to why
we develop disease. Until the last 10 years, most studies had focussed on protein‐coding …

[HTML][HTML] Current progresses and challenges of immunotherapy in triple-negative breast cancer

K Mediratta, S El-Sahli, V D'Costa, L Wang - Cancers, 2020 - mdpi.com
Simple Summary The breakthrough of immunotherapy in melanoma has generated a
glimmer of hope for lethal triple negative breast cancer (TNBC). This review summarizes the …

Recent advances on the roles of LncRNAs in cardiovascular disease

Y Fang, Y Xu, R Wang, L Hu, D Guo… - Journal of Cellular …, 2020 - Wiley Online Library
Cardiovascular diseases are a main cause of mortality whose prevalence continues to
increase worldwide. Long non‐coding RNAs (lncRNAs) regulate a variety of biological …

[HTML][HTML] Long noncoding RNA GAS5 regulates macrophage polarization and diabetic wound healing

J Hu, L Zhang, C Liechty, C Zgheib, MM Hodges… - Journal of Investigative …, 2020 - Elsevier
A central feature of diabetic (Db) wounds is the persistence of chronic inflammation, which is
partly due to the prolonged presence of proinflammatory (M1) macrophages. Using in vivo …

[HTML][HTML] Oncogenic role of PVT1 and therapeutic implications

OT Onagoruwa, G Pal, C Ochu, OO Ogunwobi - Frontiers in oncology, 2020 - frontiersin.org
PVT1, a long non-coding RNA has been implicated in a variety of human cancers. Recent
advancements have led to increasing discovery of the critical roles of PVT1 in cancer …

[HTML][HTML] The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression

R Wu, L Li, Y Bai, B Yu, C Xie, H Wu, Y Zhang… - Cell death & …, 2020 - nature.com
The long noncoding RNA (lncRNA) LUCAT1 was recently reported to be upregulated and to
play an essential role in multiple cancer types, especially colorectal cancer (CRC), but the …

[HTML][HTML] Long noncoding RNA ANRIL promotes cervical cancer development by acting as a sponge of miR-186

JJ Zhang, DD Wang, CX Du, Y Wang - Oncology research, 2018 - ncbi.nlm.nih.gov
Cervical cancer is a common malignancy of the female reproductive system. Long
noncoding RNAs (lncRNAs) have been reported to modulate tumor progression in multiple …