Fifty Years of Unraveling the Clinical Pharmacology of Corticosteroids

KE Kyler, SJ Szefler - Journal of pharmaceutical sciences, 2023 - Elsevier
This review will highlight portions of Dr. William Jusko's and colleagues' work that affected
the clinical use and study of corticosteroids in acute and chronic disease management …

Contributions of William Jusko to Development of Pharmacokinetic and Pharmacodynamic Models and Methods

DE Mager, RM Straubinger - Journal of Pharmaceutical Sciences, 2024 - Elsevier
William J. Jusko, PhD,(Fig. 1) graduated from the University of Buffalo (UB) in 1965 with a
BS degree in Pharmacy, and went on at UB to obtain a PhD degree working with Gerhard …

Influence of body condition on plasma prednisolone and prednisone concentrations in clinically healthy cats after single oral dose administration

SA Center, JF Randolph, KL Warner… - Research in veterinary …, 2013 - Elsevier
Influence of body condition (over-conditioned vs. normal-conditioned) on plasma
glucocorticoid concentrations after single dose oral prednisolone or prednisone in 11 cats (5 …

Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment

J Fu, BVJ Cuppen, PMJ Welsing… - …, 2016 - Springer
Objective As there are pharmacological differences between males and females, and
glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in …

Modeling inter-sex and inter-individual variability in response to chronopharmacological administration of synthetic glucocorticoids

ML Scherholz, RT Rao… - Chronobiology …, 2020 - Taylor & Francis
Endogenous glucocorticoids have diverse physiological effects and are important regulators
of metabolism, immunity, cardiovascular function, musculoskeletal health and central …

The physiological and pharmacological significance of the circadian timing of the HPA axis: A mathematical modeling approach

Y Li, L Lu, IP Androulakis - Journal of Pharmaceutical Sciences, 2023 - Elsevier
As a potent endogenous regulator of homeostasis, the circadian time-keeping system
synchronizes internal physiology to periodic changes in the external environment to …

Women's health and kidney protective medications

M Shankar, S Ali, S Shah - Current Opinion in Nephrology and …, 2024 - journals.lww.com
The research demonstrates that women are more likely to experience adverse events and
less likely to benefit from certain treatments, emphasizing the urgent need for healthcare …

Sex‐based differences in the response to dexamethasone in bacterial meningitis: Analysis of the European dexamethasone in adulthood bacterial meningitis study

SP Dias, MC Brouwer… - British journal of clinical …, 2020 - Wiley Online Library
Inflammatory markers have been found at higher concentrations in women than men with
bacterial meningitis. To investigate sex‐based differences in the response to …

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions

E Negera, M Tilahun, K Bobosha… - PLoS neglected …, 2018 - journals.plos.org
Background Erythema nodosum leprosum (ENL) is a systemic inflammatory complication
occurring mainly in patients with lepromatous leprosy (LL) and borderline lepromatous …

Population pharmacodynamic modeling of intramuscular and oral dexamethasone and betamethasone effects on six biomarkers with circadian complexities in Indian …

W Krzyzanski, MA Milad, AH Jobe, T Peppard… - … of Pharmacokinetics and …, 2021 - Springer
Population pharmacokinetic/pharmacodynamic (PK/PD) analysis was performed for
extensive data for differing dosage forms and routes for dexamethasone (DEX) and …