None of the physiologically based pharmacokinetic (PBPK) approaches using preclinical
data show high predictability of human pharmacokinetic (PK) profiles for drugs affected by …

La alteración en las cifras de glucosa secundaria a la administración de esteroides es un
efecto adverso conocido y frecuente en la práctica clínica, éste se asocia con mayor número …

Die glukokortikoidinduzierte Hyperglykämie ist sowohl bei Patienten mit Diabetes als auch
bei denjenigen ohne bisher bekannten Diabetes mellitus oder mit einem Prädiabetes von …

Aims (i) To model the effects of the monoclonal antibody ATM‐027 on the number of target
cells and on the receptor density on the cell surface as measured by Fluorescence Activated …

Background Hyperglycaemia is a common side effect of prednisolone, although there are no
widely accepted guidelines for the management of glucocorticoid‐induced hyperglycaemia …

Highly variable drugs have been defined as drugs with a residual variability of more than
30% in terms of the ANOVA coefficient of variation. Different approaches have been …

To develop limited-sampling strategy (LSS) models for estimating prednisolone's area under
plasma concentration versus time curve (AUC 0–∞), its maximum concentration in plasma …

Objective Corticosteroids may cause hyperglycemia and diabetes mellitus (DM).
Development of DM during long-term steroid use has been well studied; however, data …

Understanding and describing the pharmacokinetics and pharmacodynamics of therapeutic
proteins is an intriguing process. The pharmacokinetic behavior of these agents can be quite …

Men and women have fundamental anatomic and physiologic differences. Until relatively
recently, women had been underrepresented in drug trials. In part, this was to avoid …