Genotyping genetic variants of CYP2C19 for precision antiplatelet dosing: state of the art and future perspectives

N Djordjevic - Expert Opinion on Drug Metabolism & Toxicology, 2022 - Taylor & Francis
Introduction Clopidogrel is the only antiplatelet agent whose activity is significantly affected
by CYP2C19 polymorphism. Areas covered This review has summarized the available …

Antiplatelets and Anticoagulants in Vitreoretinal Surgery: A Systematic Review

F Confalonieri, V Ferraro, A Di Maria, A Gaeta… - Life, 2023 - mdpi.com
Background: Antiplatelets and anticoagulants have substantially influenced contemporary
vitreoretinal surgical practices. The availability of new oral blood thinners has recently …

Evaluating thrombosis risk and patient-specific treatment strategy using an atherothrombosis-on-chip model

F Akther, H Fallahi, J Zhang, NT Nguyen, HT Ta - Lab on a Chip, 2024 - pubs.rsc.org
Platelets play an essential role in thrombotic processes. Recent studies suggest a direct link
between increased plasma glucose, lipids, and inflammatory cytokines with platelet …

[HTML][HTML] A sticky situation: variable agreement between platelet function tests used to assess anti-platelet therapy response

H Nakahara, T Sarker, CL Dean… - Frontiers in …, 2022 - frontiersin.org
BACKGROUND: Platelet function testing to monitor antiplatelet therapy is important for
reducing thromboembolic complications, yet variability across testing methods remains …

Upgulation of lncRNA GASL1 inhibits atherosclerosis by regulating miR-106a/LKB1 axis

X Rui, X Wu, Z Rong, Z Wang - BMC Cardiovascular Disorders, 2023 - Springer
Background Atherosclerosis (AS) is a common frequently-occurring disease in the clinic and
a serious threat to human health. This research aimed to explore the value between GASL1 …

Redefining Clinically Significant Hematuria After Holmium Enucleation of the Prostate

L Hines, KM Doersch, M Ninomiya, R Jain… - Journal of …, 2023 - liebertpub.com
Introduction and Objective: Holmium laser enucleation of the prostate (HoLEP) is often
offered for symptomatic prostatic enlargement at high risk for bleeding. However, prior …

[HTML][HTML] Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease

GJ Pennings, CJ Reddel, VM Chen… - Frontiers in …, 2023 - frontiersin.org
Colchicine has been demonstrated to reduce cardiovascular death, myocardial infarction
(MI), ischemic stroke, and ischemia-driven coronary revascularization in people with …

Major Bleeding Events in Hospitalized COVID-19 Patients: A Retrospective Observational Study

A Poloni, G Casalini, G Pozza, A Giacomelli… - Medicina, 2024 - mdpi.com
Thromboprophylaxis/anticoagulation treatment is often required in hospitalized COVID-19
patients. We aimed to estimate the prevalence of major bleeding events in hospitalized …

[HTML][HTML] LncRNA HOTAIR Inhibits miR-19a-3p to Alleviate Foam Cell Formation and Inflammatory Response in Atherosclerosis

H Chen, X Li, W Chen, T Wu, S Liu - International Journal of …, 2024 - ncbi.nlm.nih.gov
Background: Atherosclerosis, a chronic inflammatory disease, poses a significant risk for
cardiovascular disorders. Meanwhile, emerging evidence suggests that long noncoding …

The Impact of CYP2C19 Genotype on the Platelet Reactivity Index (PRI) among Chronic Coronary Syndromes (CCS) Patients Undergoing Percutaneous Coronary …

MA Akkaif, NAA Daud, DAM Noor, A Sha'aban… - … Drugs and Therapy, 2024 - Springer
Abstract Background In the Asian population, the presence of the CYP2C19 loss-of-function
(LOF) allele is a known genetic variation. This allele is associated with a reduced capacity to …