In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

Messenger RNA (mRNA) translation by the ribosome represents the final step of a
complicated molecular dance from DNA to protein. Although classically considered a …

An important tenet of evolutionary developmental biology (“evo devo”) is that adaptive
mutations affecting morphology are more likely to occur in the cis-regulatory regions than in …

This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay
rates influence gene expression. mRNA stability influences gene expression in virtually all …

The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted
for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated …

Degradation of messenger RNAs (mRNAs) plays an essential role in modulation of gene
expression and in quality control of mRNA biogenesis. Nearly all major mRNA decay …

The regulation of mRNA decay is a major control point in gene expression. The stability of a
particular mRNA is controlled by specific interactions between its structural elements and …

Secondary hyperparathyroidism classically appears during the course of chronic renal
failure and sometimes after renal transplantation. Understanding the mechanisms by which …

Based on the above mechanisms of mRNA degradation, an integrated model of mRNA
turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be …

Labile mRNAs that encode cytokine and immediate-early gene products often contain AU-
rich sequences within their 3′ untranslated region (UTR). These AU-rich sequences …