MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …

The formation of pre-metastatic niche is a key step in the metastatic burden. The pluripotent
factor Lin28B is frequently expressed in breast tumors and is particularly upregulated in the …

The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while
the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We …

Identification of the factors critical to the tumor-initiating cell (TIC) state may open new
avenues in cancer therapy. Here we show that the metabolic enzyme glycine decarboxylase …

In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors
that define stemness in several tissue lineages. Lin28 proteins repress let-7 microRNAs and …

Chromatin remodeling proteins are frequently dysregulated in human cancer, yet little is
known about how they control tumorigenesis. Here, we uncover an epigenetic program …

Abstract Changes in the patterns of gene expression are widely believed to underlie many of
the phenotypic differences within and between species. Although much emphasis has been …

Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue
repair remains unexplained. Lin28a, a highly conserved RNA-binding protein expressed …