Towards a mechanistic model of tau-mediated pathology in tauopathies: what can we learn from cell-based in vitro assays?
J Sala-Jarque, K Zimkowska, J Ávila, I Ferrer… - International Journal of …, 2022 - mdpi.com
Tauopathies are a group of neurodegenerative diseases characterized by the
hyperphosphorylation and deposition of tau proteins in the brain. In Alzheimer's disease …
hyperphosphorylation and deposition of tau proteins in the brain. In Alzheimer's disease …
Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p. Ile416Thr variant mirror Alzheimer's disease neuropathology
N Gomez-Sequeda, M Mendivil-Perez… - Scientific Reports, 2023 - nature.com
Familial Alzheimer's disease (FAD) is a complex neurodegenerative disorder for which there
are no therapeutics to date. Several mutations in presenilin 1 (PSEN 1), which is the catalytic …
are no therapeutics to date. Several mutations in presenilin 1 (PSEN 1), which is the catalytic …
Functional Characterisation of the Circular RNA, circHTT(2-6), in Huntington's Disease
L Gantley, BW Stringer, VM Conn, Y Ootsuka, D Holds… - Cells, 2023 - mdpi.com
Trinucleotide repeat disorders comprise~ 20 severe, inherited, human neuromuscular and
neurodegenerative disorders, which result from an abnormal expansion of repetitive …
neurodegenerative disorders, which result from an abnormal expansion of repetitive …
Fiscalin Derivatives as Potential Neuroprotective Agents
S Barreiro, B Silva, S Long, M Pinto, F Remião… - Pharmaceutics, 2022 - mdpi.com
Neurodegenerative diseases (ND) share common molecular/cellular mechanisms that
contribute to their progression and pathogenesis. In this sense, we are here proposing new …
contribute to their progression and pathogenesis. In this sense, we are here proposing new …
(BIO) ANALYTICAL APPROACHES FOR INVESTIGATING THE ROLE OF SELENIUM IN PREVENTING NEUROLOGICAL DISORDERS AND NEUROTOXICITY …
B Gómez-Gómez, T Fernández-Bautista… - TrAC Trends in Analytical …, 2024 - Elsevier
There is increasing evidence that dysfunction of essential metal (Cu, Zn, Fe, Mn)
homeostasis can lead to the appearance of several NDs. Other neurotoxic environmental …
homeostasis can lead to the appearance of several NDs. Other neurotoxic environmental …
Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters
RW Tam, AJ Keung - Molecular and Cellular Neuroscience, 2023 - Elsevier
Transcriptomic responses to neurotransmitters contribute to the complex processes driving
memory and addiction. Advances in both measurement methods and experimental models …
memory and addiction. Advances in both measurement methods and experimental models …
Roadbumps at the Crossroads of Integrating Behavioral and In Vitro Approaches for Neurotoxicity Assessment
GJ Harry, S Mcbride, SK Witchey… - Frontiers in …, 2022 - frontiersin.org
With the appreciation that behavior represents the integration and complexity of the nervous
system, neurobehavioral phenotyping and assessment has seen a renaissance over the last …
system, neurobehavioral phenotyping and assessment has seen a renaissance over the last …
[HTML][HTML] Tantalum doped TiO2 nanoparticles induced cytotoxicity and DNA damage through ROS generation in human neuroblastoma cells
The chemoradiotherapy technique is widely applied in the treatment of cancerous disease.
Nowadays, nanoparticles are used in drug delivery and it is essential to confirm the …
Nowadays, nanoparticles are used in drug delivery and it is essential to confirm the …
The path to progress preclinical studies of age-related neurodegenerative diseases: a perspective on rodent and hiPSC-derived models
G MacDougall, LY Brown, B Kantor, O Chiba-Falek - Molecular Therapy, 2021 - cell.com
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent age-
related neurodegenerative diseases, and currently no effective clinical treatments exist for …
related neurodegenerative diseases, and currently no effective clinical treatments exist for …
Small‑molecule PKR‑like endoplasmic reticulum kinase inhibitors as a novel targeted therapy for Parkinson's disease
W Lusa, W Rozpędek-Kamińska… - Molecular …, 2023 - spandidos-publications.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder in
worldwide and remains a therapeutic challenge due to the low efficacy of current treatments …
worldwide and remains a therapeutic challenge due to the low efficacy of current treatments …