The nature of the transition from acute to chronic pain still eludes explanation, but chronic
pain resulting from surgery provides a natural experiment that invites clinical …

Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …

Opioid use for pain management has dramatically increased, with little assessment of
potential pathophysiological consequences for the primary pain condition. Here, a short …

As early as the 19th century, OIH was observed in patients receiving morphine for pain. It
was recognized that a potent analgesic such as morphine could actually result in an …

It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

Chronic pain is a pervasive problem that affects the patient, their significant others, and
society in many ways. The past decade has seen advances in our understanding of the …

Although postoperative pain remains incompletely controlled in some settings, increased
understanding of its mechanisms and the development of several therapeutic approaches …

Objective: Opioid pharmacotherapy is now the leading treatment for chronic pain, a problem
that affects nearly one third of the US population. Given the dramatic rise in prescription …

Homeostasis, the dominant explanatory framework for physiological regulation, has
undergone significant revision in recent years, with contemporary models differing …

In patients with active cancer, the management of chronic pain is an essential element in a
comprehensive strategy for palliative care. This strategy emphasises multidimensional …