Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription
Y Zhang, H Song, M Li, P Lu - Clinical and Translational …, 2024 - Wiley Online Library
Heightened lactate production in cancer cells has been linked to various cellular
mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell …
mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell …
[HTML][HTML] Stable Isotope Tracing Analysis in Cancer Research: Advancements and Challenges in Identifying Dysregulated Cancer Metabolism and Treatment …
Metabolic reprogramming is a hallmark of cancer, driving the development of therapies
targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool …
targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool …
Exploring the potential of asparagine restriction in solid cancer treatment: recent discoveries, therapeutic implications, and challenges
MG Fontes, C Silva, WH Roldán, G Monteiro - Medical Oncology, 2024 - Springer
Asparagine is a non-essential amino acid crucial for protein biosynthesis and function, and
therefore cell maintenance and growth. Furthermore, this amino acid has an important role …
therefore cell maintenance and growth. Furthermore, this amino acid has an important role …
DON of Hope: Starving Pancreatic Cancer by Glutamine Antagonism
R Pillai, T Papagiannakopoulous - Cancer Research, 2024 - AACR
A promising approach to treat solid tumors involves disrupting their reliance on glutamine, a
key component for various metabolic processes. Traditional attempts using glutamine …
key component for various metabolic processes. Traditional attempts using glutamine …
[HTML][HTML] Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) subsists in a nutrient-deregulated
microenvironment, making it particularly susceptible to treatments that interfere with cancer …
microenvironment, making it particularly susceptible to treatments that interfere with cancer …
Therapeutic resurgence of 6-diazo-5-oxo-L-norleucine (DON) through tissue-targeted prodrugs
K Novotná, L Tenora, BS Slusher… - Advances in …, 2024 - pure.johnshopkins.edu
The recognition that rapidly proliferating cancer cells rely heavily on glutamine for their
survival and growth has renewed interest in the development of glutamine antagonists for …
survival and growth has renewed interest in the development of glutamine antagonists for …
CANCER-ASSOCIATED FIBROBLASTS MAINTAIN PANCREATIC CANCER CELL LIPID HOMEOSTASIS IN THE TUMOR MICROENVIRONMENT
X Han - 2024 - repository.upenn.edu
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy whose
abundant cancer-associated fibroblasts (CAFs) create a hallmark “desmoplasia” that …
abundant cancer-associated fibroblasts (CAFs) create a hallmark “desmoplasia” that …
[HTML][HTML] Exploiting pancreatic cancer metabolism: challenges and opportunities
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer,
known for its challenging diagnosis and limited treatment options. The focus on metabolic …
known for its challenging diagnosis and limited treatment options. The focus on metabolic …