Implication of COVID-19 on erythrocytes functionality: red blood cell biochemical implications and morpho-functional aspects
Several diseases (such as diabetes, cancer, and neurodegenerative disorders) affect the
morpho-functional aspects of red blood cells, sometimes altering their normal metabolism. In …
morpho-functional aspects of red blood cells, sometimes altering their normal metabolism. In …
Current evidence in SARS-CoV-2 mRNA vaccines and post-vaccination adverse reports: knowns and unknowns
DS Mouliou, E Dardiotis - Diagnostics, 2022 - mdpi.com
The novel mRNA vaccinations against COVID-19 are gaining worldwide attention for their
potential efficacy, as well as for the diagnosis of some post-vaccination-reported adverse …
potential efficacy, as well as for the diagnosis of some post-vaccination-reported adverse …
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …
The mechanisms of ferroptosis under hypoxia
X Gao, W Hu, D Qian, X Bai, H He, L Li… - Cellular and Molecular …, 2023 - Springer
Ferroptosis is a new form of programmed cell death, which is characterized by the iron-
dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative …
dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative …
Red blood cell-derived extracellular vesicles display endogenous antiviral effects and enhance the efficacy of antiviral oligonucleotide therapy
MK Jayasinghe, C Gao, G Yap, BZJ Yeo, LT Vu… - ACS …, 2023 - ACS Publications
The COVID-19 pandemic has resulted in a large number of fatalities and, at present, lacks a
readily available curative treatment for patients. Here, we demonstrate that unmodified red …
readily available curative treatment for patients. Here, we demonstrate that unmodified red …
Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?
In severe COVID-19, the levels of iron (Fe), copper (Cu), zinc (Zn) and selenium (Se), do not
only regulate host immune responses, but modify the viral genome, as well. While low serum …
only regulate host immune responses, but modify the viral genome, as well. While low serum …
Heme binding to the SARS-CoV-2 spike glycoprotein
SL Freeman, ASF Oliveira, AE Gallio, A Rosa… - Journal of Biological …, 2023 - ASBMB
The target for humoral immunity, SARS-CoV-2 spike glycoprotein, has become the focus of
vaccine research and development. Previous work demonstrated that the N-terminal domain …
vaccine research and development. Previous work demonstrated that the N-terminal domain …
Photomedicine based on heme-derived compounds
Photoimaging and phototherapy have become major platforms for the diagnosis and
treatment of various health complications. These applications require a photosensitizer (PS) …
treatment of various health complications. These applications require a photosensitizer (PS) …
SARS-CoV-2 infection dysregulates host iron (Fe)-redox homeostasis (Fe-RH): role of Fe-redox regulators, ferroptosis inhibitors, anticoagulants, and iron-chelators in …
SAG Naidu, RA Clemens, AS Naidu - Journal of dietary …, 2023 - Taylor & Francis
Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in
every symptomatic (mild, moderate to severe) clinical phase of COVID-19. Phase-I–Hypoxia …
every symptomatic (mild, moderate to severe) clinical phase of COVID-19. Phase-I–Hypoxia …
Association of iron-related biomarkers with severity and mortality in COVID-19 patients
D Yadav, KK Pvsn, S Tomo, S Sankanagoudar… - Journal of Trace …, 2022 - Elsevier
Background Nutritional deficiency is associated with weaken immune system and increased
susceptibility to infection. Among other nutrients, several trace elements have been shown to …
susceptibility to infection. Among other nutrients, several trace elements have been shown to …