Cytomegalovirus in transplantation – challenging the status quo

JA Fishman, V Emery, R Freeman… - Clinical …, 2007 - Wiley Online Library
Background: Cytomegalovirus (CMV) infection of solid organ transplant (SOT) recipients
causes both ''direct''and ''indirect''effects including allograft rejection, decreased graft and …

Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients

B Nashan, R Gaston, V Emery, MD Säemann… - …, 2012 - journals.lww.com
Cytomegalovirus (CMV) infection and disease are major complications in the renal
transplant recipient. The occurrence of CMV is associated with acute rejection, allograft …

Overview of the diagnosis of cytomegalovirus infection

SA Ross, Z Novak, S Pati… - Infectious Disorders-Drug …, 2011 - ingentaconnect.com
Cytomegalovirus (CMV) is recognized as the most common congenital viral infection in
humans and an important cause of morbidity and mortality in immunocompromised hosts …

[HTML][HTML] Impact of antiviral preventive strategies on the incidence and outcomes of cytomegalovirus disease in solid organ transplant recipients

O Manuel, G Kralidis, NJ Mueller, HH Hirsch… - American journal of …, 2013 - Elsevier
We assessed the impact of antiviral prophylaxis and preemptive therapy on the incidence
and outcomes of cytomegalovirus (CMV) disease in a nationwide prospective cohort of solid …

Cytomegalovirus and polyomavirus BK posttransplant

A Egli, S Binggeli, S Bodaghi… - Nephrology Dialysis …, 2007 - academic.oup.com
Virus replication and progression to disease in transplant patients is determined by patient-,
graft-and virus-specific factors. This complex interaction is modulated by the net state of …

[HTML][HTML] The impact of cytomegalovirus infection on new-onset diabetes mellitus after kidney transplantation: a review on current findings

B Einollahi, M Motalebi, M Salesi… - Journal of …, 2014 - ncbi.nlm.nih.gov
Context: New onset diabetes mellitus after transplantation (NODAT) increases the risk of
cardiovascular disease, rate of infections, graft rejection and graft loss as well as decreases …

Why hasn't eliminating acute rejection improved graft survival?

JR Tantravahi, KL Womer, B Kaplan - Annu. Rev. Med., 2007 - annualreviews.org
Although patients with end-stage renal disease can be maintained with dialysis therapy, the
superiority of patient survival with renal transplantation makes transplantation the preferred …

A genome‐wide association study of recipient genotype and medium‐term kidney allograft function

RP O'Brien, PJ Phelan, J Conroy, P O'Kelly… - Clinical …, 2013 - Wiley Online Library
Background We examined, through genome‐wide association studies (GWAS), the
correlation between recipient genetic variation and renal function at five yr. Methods Our …

Biology of human pentraxin 3 (PTX3) in acute and chronic kidney disease

MM Speeckaert, R Speeckaert, JJ Carrero… - Journal of Clinical …, 2013 - Springer
The pentraxin superfamily consists of highly conserved multimeric pattern recognition
proteins, which are components of the humoral arm of innate immunity. Besides the classical …

Association between a polymorphism in the human programmed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplantation

TW Hoffmann, JM Halimi, M Büchler… - Journal of medical …, 2010 - jmg.bmj.com
Background Cytomegalovirus (CMV) infection is the most frequent infectious disease
following organ transplantation. Strategies to prevent this infection remain a matter for …