Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies | New England Journal
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Clear evidence supports a genetic basis for substance use disorders (SUD). Yet, the search
to identify individual gene contributions to SUD has been unsuccessful. Here, we argue for …

Substance use disorders (SUDs) manifest as chronic relapsing disorders, characterized by
compulsive drug taking despite serious adverse consequences, the loss of control over …

Drug addiction, one of the major health problems worldwide, is characterized by the loss of
control in drug intake, craving, and withdrawal. At the individual level, drugs of abuse …

Drug addiction involves long-term behavioral abnormalities that arise in response to
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …

Interest in the habenula has greatly increased in recent years. The habenula is a small brain
structure located posterior to the thalamus and adjacent to the third ventricle. Despite its …

The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human
genetic studies of addiction. Because of its potential functional significance, the non …

Opioid addiction and overdose are at record levels in the United States. This is driven, in
part, by their widespread prescription for the treatment of pain, which also increased …

Интернет-зависимость (ИЗ) признана одним из распространенных вариантов
аддиктивных нарушений нехимической природы и имеет значительные негативные …

Rationale Most substance use is initiated during adolescence when substantial
development of relevant brain circuitry is still rapidly maturing. Developmental differences in …