Epidermal growth factor receptors (EGFRs) are a class of receptor tyrosine kinase that are
also called ErbB1 and HER1. EGFR tyrosine kinase activity inhibition is considered a …

Angiogenesis, the formation of new blood vessels from the existing vasculature, is pivotal in
the migration, growth, and differentiation of endothelial cells in normal physiological …

Cas12f is a hypercompact type V, Cas12 family member. Previously, we reported a set of
engineered guide RNAs supporting high indel efficiency for Cas12f1 in human cells. Here …

Head and neck cancer (HNC) concerns more than 890,000 patients worldwide annually and
is associated with the advanced stage at presentation and heavy outcomes. Alcohol …

Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …

As the hub connecting mother and offspring, the placenta's normal development is vital for
fetal growth. Fear stress can cause some structural alterations in the placenta and affect …

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes in translation by linking amino
acids onto their cognate tRNAs during protein synthesis. During evolution, aaRSs develop …

The advent of targeted therapies has led to tremendous improvements in treatment options
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …

As the third most severe cancer in the world, colorectal cancer (CRC) is of high concern to
global health concerns. Aging, unhealthy lifestyles, and genetic factors contribute to CRC …

Small-molecule EGFR inhibitors have distinctly improved the overall survival especially in
EGFR-mutated lung cancer. However, their use is often limited by severe adverse effects …