Neuroinflammation and fibrosis in stroke: The good, the bad and the ugly

N Amruta, AA Rahman, E Pinteaux, G Bix - Journal of neuroimmunology, 2020 - Elsevier
Stroke is the leading cause of death and the main cause of disability in surviving patients.
The detrimental interaction between immune cells, glial cells, and matrix components in …

Investigating the Potential Mechanisms and Therapeutic Targets of Inflammatory Cytokines in Post-stroke Depression

Y Zhang, Y Yang, H Li, Q Feng, W Ge, X Xu - Molecular Neurobiology, 2024 - Springer
Post-stroke depression (PSD) affects approximately one-third of stroke survivors, severely
impacting general recovery and quality of life. Despite extensive studies, the exact …

[HTML][HTML] Vagus nerve stimulation alleviated cerebral ischemia and reperfusion injury in rats by inhibiting pyroptosis via α7 nicotinic acetylcholine receptor

H Tang, J Li, Q Zhou, S Li, C Xie, L Niu, J Ma… - Cell death discovery, 2022 - nature.com
Cumulative evidence suggests that pyroptosis, a new sort of programmed cell death, is
closely related to cerebral ischemia/reperfusion (I/R) injury. Our previous studies have …

Interleukin-18 from neurons and microglia mediates depressive behaviors in mice with post-stroke depression

D Wu, G Zhang, C Zhao, Y Yang, Z Miao… - Brain, behavior, and …, 2020 - Elsevier
Post-stroke depression (PSD) is a common and serious complication that is affecting one
thirds of stroke patients which leaves them with a poor quality of life, high mortality rate, high …

[HTML][HTML] Gut microbiota composition reflects disease progression, severity and outcome, and dysfunctional immune responses in patients with hypertensive …

J Luo, Y Chen, G Tang, Z Li, X Yang, X Shang… - Frontiers in …, 2022 - frontiersin.org
Objective In this study, we aimed to explore the alterations in gut microbiota composition and
cytokine responses related to disease progression, severity, and outcomes in patients with …

Interleukin‐18 mediated inflammatory brain injury after intracerebral hemorrhage in male mice

H Li, J Tian, Y Yin, S Diao, X Zhang… - Journal of …, 2022 - Wiley Online Library
Abstract Interleukin‐18 (IL‐18), a pro‐inflammatory cytokine, is thought to be associated with
inflammation in many neurological diseases such as ischemic stroke and poststroke …

[HTML][HTML] Red blood cell distribution width is associated with neuronal damage in acute ischemic stroke

RH Hong, J Zhu, ZZ Li, J Yuan, P Zhao, J Ding… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Elevated red blood cell distribution width (RDW) has been found to be associated with the
occurrence of ischemic stroke. However, there is no defined relationship between RDW and …

Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats

Y Ren, J Jiang, W Jiang, X Zhou, W Lu, J Wang… - Neurochemical …, 2021 - Springer
Brain inflammation induced by ischemic stroke is an important cause of secondary brain
injury. The nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and …

[HTML][HTML] Vinpocetine attenuates ischemic stroke through inhibiting NLRP3 inflammasome expression in mice

D Han, J Wang, L Wen, M Sun, H Liu… - Journal of …, 2021 - journals.lww.com
Ischemic stroke is the leading cause of globe death and permanent disability, but its
therapeutic strategies are limited. Over the past decades, multiprotein complexes called …

Exploring causal association between circulating inflammatory cytokines and functional outcomes following ischemic stroke: A bidirectional Mendelian randomization …

H Liu, Z Liu, Y Huang, Q Ding, Z Lai… - European Journal of …, 2024 - Wiley Online Library
Objectives Previous observational studies have indicated correlations between various
inflammatory cytokines and functional outcomes following ischemic stroke (IS); however, the …