[HTML][HTML] Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

AA Bhat, P Yousuf, NA Wani, A Rizwan… - Signal transduction and …, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor
prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have …

[HTML][HTML] Current and emerging molecular therapies for head and neck squamous cell carcinoma

F Kordbacheh, CS Farah - Cancers, 2021 - mdpi.com
Simple Summary Next-generation sequencing of head and neck squamous cell carcinoma
has revealed multiple new gene mutations, while simultaneously confirming the role of …

[HTML][HTML] The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: A multiparametric quantitative and spatial …

A Tosi, B Parisatto, A Menegaldo, G Spinato… - Journal of Experimental …, 2022 - Springer
Background Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or
metastatic oropharyngeal head and neck squamous cell carcinoma in the first-and second …

[HTML][HTML] Identification of the MMP family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma

M Liu, L Huang, Y Liu, S Yang, Y Rao, X Chen… - Journal of Translational …, 2023 - Springer
Abstract Background Head and Neck Squamous Cell Carcinoma is a malignant tumor with
high morbidity and mortality. The MMP family plays an important role in tumor invasion and …

[HTML][HTML] On-treatment immune prognostic score for patients with relapsed and/or metastatic head and neck squamous cell carcinoma treated with immunotherapy

P Nenclares, L Gunn, H Soliman, M Bover… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Previous studies have suggested that inflammatory markers (neutrophil-to-
lymphocyte ratio (NLR), lactate dehydrogenase (LDH) and fibrinogen) are prognostic …

[HTML][HTML] Immunotherapy in head and neck cancer when, how, and why?

D Pereira, D Martins, F Mendes - Biomedicines, 2022 - mdpi.com
Head and neck cancer (HNC) is one of the most common cancers worldwide. Alcohol and
tobacco consumption, besides viral infections, are the main risk factors associated with this …

[HTML][HTML] Checkpoint inhibitors in cancer therapy: clinical benefits for head and neck cancers

T Ettl, M Grube, D Schulz, RJ Bauer - Cancers, 2022 - mdpi.com
Simple Summary In recent years, checkpoint inhibitor treatment of tumors has caused a stir.
The response of patients with metastases showed outstanding success for some cancer …

[HTML][HTML] High risk-human papillomavirus in HNSCC: Present and future challenges for epigenetic therapies

L Ghiani, S Chiocca - International Journal of Molecular Sciences, 2022 - mdpi.com
Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly heterogeneous group of
tumors characterized by an incidence of 650,000 new cases and 350,000 deaths per year …

[HTML][HTML] The miR‑136‑5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells

B Yang, J Zang, W Yuan… - Experimental and …, 2021 - spandidos-publications.com
Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma
(HPSCC) are two types of head and neck cancers with high incidence rates and relatively …

[HTML][HTML] Prognostic significance of PD-L1 expression in patients with primary oropharyngeal squamous cell carcinoma: a meta-analysis

J Polesel, A Menegaldo, G Tirelli, V Giacomarra… - Frontiers in …, 2021 - frontiersin.org
Background At present, the prognostic significance of programmed cell death receptor
ligand 1 (PD-L1) expression in oropharyngeal squamous cell carcinoma (OPSCC) patients …