[HTML][HTML] The effects of type 2 diabetes mellitus on organ metabolism and the immune system

G Daryabor, MR Atashzar, D Kabelitz, S Meri… - Frontiers in …, 2020 - frontiersin.org
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

[HTML][HTML] Nox4 as a novel therapeutic target for diabetic vascular complications

D Wang, J Li, G Luo, J Zhou, N Wang, S Wang, R Zhao… - Redox Biology, 2023 - Elsevier
Diabetic vascular complications can affect both microvascular and macrovascular. Diabetic
microvascular complications, such as diabetic nephropathy, diabetic retinopathy, diabetic …

[HTML][HTML] Dihydromyricetin protects against high glucose-induced endothelial dysfunction: Role of HIF-1α/ROR2/NF-κB

EM Awad, ASF Ahmed, M El-Daly, AH Amin… - Biomedicine & …, 2022 - Elsevier
Objectives Dihydromyricetin (DHM), a natural flavonoid isolated from vine tea with anti-
inflammatory activity was evaluated for its ability to prevent vascular endothelial dysfunction …

Apocynin ameliorates NADPH oxidase 4 (NOX4) induced oxidative damage in the hypoxic human retinal Müller cells and diabetic rat retina

A Ahmad, MI Nawaz, MM Siddiquei… - Molecular and Cellular …, 2021 - Springer
NADPH oxidase (NOX) is a main producers of reactive oxygen species (ROS) that may
contribute to the early pathogenesis of diabetic retinopathy (DR). ROS has harmful effects on …

Long non-coding RNA H19, a negative regulator of microRNA-148b-3p, participates in hypoxia stress in human hepatic sinusoidal endothelial cells via NOX4 and …

Y Zhu, T Ni, J Lin, C Zhang, L Zheng, M Luo - Biochimie, 2019 - Elsevier
This study aimed at the participation of lncRNA H19, endothelial NADPH oxidases (NOX4)
and miR-148b-3p in hypoxia stress in human hepatic sinusoidal endothelial cells (HHSEC) …

Fluoxetine induces apoptosis through extrinsic/intrinsic pathways and inhibits ERK/NF-κB-modulated anti-apoptotic and invasive potential in hepatocellular carcinoma …

WT Chen, FT Hsu, YC Liu, CH Chen, LC Hsu… - International Journal of …, 2019 - mdpi.com
The aim of the present study was to verify the effects of fluoxetine on dysregulation of
apoptosis and invasive potential in human hepatocellular carcinoma (HCC) SK-Hep1 and …

Identification of the antithrombotic mechanism of leonurine in adrenalin hydrochloride-induced thrombosis in zebrafish via regulating oxidative stress and coagulation …

L Liao, M Zhou, J Wang, X Xue, Y Deng… - Frontiers in …, 2021 - frontiersin.org
Thrombosis is a general pathological phenomenon during severe disturbances to
homeostasis, which plays an essential role in cardiovascular and cerebrovascular diseases …

Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury

S Alzahrani, E Said, SM Ajwah… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives The current study provides evidence on the ameliorative impact of
Isoliquiritigenin (ISL), a natural bioflavonoid isolated from licorice roots against diabetes …

[HTML][HTML] Retinal physiology and circulation: effect of diabetes

WS Wright, RS Eshaq, M Lee, G Kaur… - Comprehensive …, 2020 - ncbi.nlm.nih.gov
In this review, we present a discussion of diabetes and its complications, including the
macrovascular and microvascular effects, with the latter of consequence to the retina. We …

[HTML][HTML] Long non-coding RNAs in the pathogenesis of diabetic kidney disease

M Hu, Q Ma, B Liu, Q Wang, T Zhang… - Frontiers in Cell and …, 2022 - frontiersin.org
Diabetic kidney disease (DKD) is one of the major microvascular complications of diabetes
mellitus, with relatively high morbidity and mortality globally but still in-short therapeutic …