How does adenosine control neuronal dysfunction and neurodegeneration?
RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
Adenosine receptors: expression, function and regulation
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …
mediate the physiological actions of adenosine. To date, four AR subtypes have been …
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors—an update
BB Fredholm, AP IJzerman, KA Jacobson… - Pharmacological …, 2011 - ASPET
In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …
report on the nomenclature and classification of adenosine receptors, no developments …
Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity
The combination of aging populations with the obesity pandemic results in an alarming rise
in non-communicable diseases. Here, we show that the enigmatic adenosine A2B receptor …
in non-communicable diseases. Here, we show that the enigmatic adenosine A2B receptor …
Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling
MJ Lohse, S Nuber, C Hoffmann - Pharmacological reviews, 2012 - ASPET
Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …
techniques allow the sensitive monitoring of distances between two labels at the nanometer …
Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade
RA Cunha - Purinergic signalling, 2005 - Springer
Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …
Targeting adenosine A2A receptors in Parkinson's disease
MA Schwarzschild, L Agnati, K Fuxe, JF Chen… - Trends in …, 2006 - cell.com
The adenosine A 2A receptor has emerged as an attractive non-dopaminergic target in the
pursuit of improved therapy for Parkinson's disease (PD), based in part on its unique CNS …
pursuit of improved therapy for Parkinson's disease (PD), based in part on its unique CNS …
A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer
Bioluminescence resonance energy transfer (BRET), which relies on nonradiative energy
transfer between luciferase-coupled donors and GFP-coupled acceptors, is emerging as a …
transfer between luciferase-coupled donors and GFP-coupled acceptors, is emerging as a …
Adenosine receptor–dopamine receptor interactions in the basal ganglia and their relevance for brain function
The dopamine D1 and D2 receptors are major receptors in the regulation of striatal function
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …
Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function
The existence of A 2A-D 2 heteromeric complexes is based on coimmunoprecipitation
studies and on fluorescence resonance energy transfer and bioluminescence resonance …
studies and on fluorescence resonance energy transfer and bioluminescence resonance …