The conditional depletion of a protein of interest (POI) is useful not only for loss-of-function
studies, but also for the modulation of biological pathways. Technologies that work at the …

Chemical probes of epigenetic 'readers' of histone post-translational modifications (PTMs)
have become powerful tools for mechanistic and functional studies of their target proteins in …

Thorough preclinical target validation is essential for the success of drug discovery efforts. In
this study, we combined chemical and genetic perturbants, including the development of a …

Inducing protein degradation via small molecules is a transformative therapeutic paradigm.
Although structural requirements of target degradation are emerging, mechanisms …

Recent studies have indicated that nucleosome turnover is rapid, occurring several times
per cell cycle. To access the effect of nucleosome turnover on the epigenetic landscape, we …

Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in
human cancers, including pancreatic ductal adenocarcinoma (PDAC). While Pin1 is …

Proteolysis-targeting chimeras (PROTACs) bring a protein of interest (POI) into spatial
proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and proteasomal …

Simple Summary Gene inactivation is a powerful strategy to study the function of specific
proteins in the context of cellular physiology that can be applied for only non-essential …

Leukemic blasts are immune cells gone awry. We hypothesized that dysregulation of
inflammatory pathways contributes to the maintenance of their leukemic state and can be …

Leukemias driven by chromosomal translocation of the mixed-lineage leukemia gene (MLL
or KMT2A) are highly prevalent in pediatric oncology. The poor survival rate and lack of an …