Gain-of-function mutations in the histone acetylation “reader” eleven-nineteen-leukemia
(ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive …

Acute myeloid and lymphoid leukemias often harbor chromosomal translocations involving
the KMT2A gene, encoding the KMT2A lysine methyltransferase (also known as mixed …

Identification of novel functional domains and characterization of detailed regulatory
mechanisms in cancer-driving genes is critical for advanced cancer therapy. To date …

Protein acetylation is a reversible post-translational modification, and is involved in many
biological processes in cells, such as transcriptional regulation, DNA damage repair, and …

Previously, we showed that CDYL1 is recruited to DNA double-strand breaks (DSBs) to
promote homologous recombination (HR) repair and foster transcriptional silencing …

Epigenetic reader proteins interpret histone epigenetic marks to regulate gene expression.
Given their vital roles and the link between their dysfunction and various diseases, these …

Click chemistry is universally recognized as a powerful strategy for the fast and precise
assembly of diverse building blocks. Targeted Protein Degradation (TPD) is a new …

Conspectus The hereditary blueprint of a eukaryotic cell is encoded in its genomic DNA that
is tightly compacted into chromatin together with histone proteins. The basic repeating units …

Interpretation of the histone posttranslational modifications (PTMs) by effector proteins, or
readers, is an important epigenetic mechanism to regulate gene function. YEATS domains …

Histone lysine methylation is a post-translational modification that plays a key role in the
epigenetic regulation of a broad spectrum of biological processes. Moreover, the …