Significance: Mitochondria undergo constant morphological changes through fusion, fission,
and mitophagy. As the key organelle in cells, mitochondria are responsible for numerous …

B-cell receptor-associated protein 31 (BAP31 or BCAP31) is a ubiquitously expressed
transmembrane protein found mainly in the endoplasmic reticulum (ER), including in …

Despite novel therapy regimens and extensive research, chemoresistance remains a
challenge in leukemia treatment. Of note, recent studies revealed lysosomes as regulators of …

Primarily responsible for the biogenesis and metabolism of biomolecules, endoplasmic
reticulum (ER) and mitochondria are gradually becoming the targets of therapeutic …

Since cancer cells have different mitochondrial bioenergetic requirements than non-
cancerous cells, therapeutic inhibition of its mitochondrial functionality continues to be an …

The surrounding non-cancer cells and tumor cells that make up the tumor microenvironment
(TME) have various metabolic rhythms. TME metabolic heterogeneity is influenced by the …

Cell fate is critically affected by mitochondrial activity, from ATP production to metabolism,
Ca 2+ homeostasis and signaling. These actions are regulated by proteins expressed in …

Oxidoreductase protein disulphide isomerases (PDI) are involved in the regulation of a
variety of biological processes including the modulation of endoplasmic reticulum (ER) …

Mitochondria not only are essential for cell metabolism and energy supply but are also
engaged in calcium homeostasis and reactive oxygen species generation and play a key …

Lagunamide A is a biologically active natural product with a yet unidentified molecular mode
of action. Cellular studies revealed that lagunamide A is a potent inhibitor of cancer cell …