Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

The field of research in bladder cancer has seen significant advances in recent years. Next-
generation sequencing has identified the genes most mutated in bladder cancer. This …

Neoadjuvant chemotherapy (NAC) prior to surgery and immune checkpoint therapy (ICT)
have revolutionized bladder cancer management. However, stratification of patients that …

Bladder cancer represents a highly heterogeneous disease characterized by distinct
histological, molecular and clinical phenotypes, and a detailed analysis of tumor cell …

Purpose: Bladder cancer treatment remains a major clinical challenge due to therapy
resistance and a high recurrence rate. Profiling intratumor heterogeneity can reveal the …

Cisplatin-based chemotherapy remains the primary treatment for unresectable and
metastatic muscle-invasive bladder cancers (MIBCs). However, tumors frequently develop …

Immunotherapies such as immune checkpoint blockade and adoptive cell transfer have
revolutionized cancer treatment, but further progress is hindered by our limited …

Purpose: On the basis of preclinical evidence of epigenetic contribution to sensitivity and
resistance to immune checkpoint inhibitors (ICI), we hypothesized that guadecitabine …

Inflammatory cancer-associated fibroblasts (iCAFs) are closely related to progression,
anticancer therapeutic resistance, and poor prognosis of bladder cancer (BCa). However …

The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …