Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

CK Negi, P Babica, L Bajard, J Bienertova-Vasku… - Metabolism, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
worldwide. With no Food and Drug Administration approved drugs, current treatment options …

Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

[HTML][HTML] Human health and ocean pollution

PJ Landrigan, JJ Stegeman, LE Fleming… - Annals of global …, 2020 - ncbi.nlm.nih.gov
Background: Pollution–unwanted waste released to air, water, and land by human activity–is
the largest environmental cause of disease in the world today. It is responsible for an …

[HTML][HTML] Overview of known plastic packaging-associated chemicals and their hazards

KJ Groh, T Backhaus, B Carney-Almroth… - Science of the total …, 2019 - Elsevier
Global plastics production has reached 380 million metric tons in 2015, with around 40%
used for packaging. Plastic packaging is diverse and made of multiple polymers and …

Obesity II: Establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

[PDF][PDF] A quantitative proteome map of the human body

L Jiang, M Wang, S Lin, R Jian, X Li, J Chan, G Dong… - Cell, 2020 - cell.com
Determining protein levels in each tissue and how they compare with RNA levels is
important for understanding human biology and disease as well as regulatory processes …

[HTML][HTML] A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics

J Sun, R Fang, H Wang, DX Xu, J Yang, X Huang… - Environment …, 2022 - Elsevier
Humans are exposed to an ever-increasing number of environmental toxicants, some of
which have gradually been elucidated to be important risk factors for metabolic diseases …

[HTML][HTML] Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring

V Mustieles, SC d'Cruz, S Couderq… - Environment …, 2020 - Elsevier
Human biomonitoring (HBM) studies have demonstrated widespread and daily exposure to
bisphenol A (BPA). Moreover, BPA structural analogues (eg BPS, BPF, BPAF), used as BPA …

Update on the health effects of bisphenol A: overwhelming evidence of harm

FS Vom Saal, LN Vandenberg - Endocrinology, 2021 - academic.oup.com
In 1997, the first in vivo bisphenol A (BPA) study by endocrinologists reported that feeding
BPA to pregnant mice induced adverse reproductive effects in male offspring at the low dose …

[HTML][HTML] Non-targeted metabolomics and associations with per-and polyfluoroalkyl substances (PFAS) exposure in humans: A scoping review

P Guo, T Furnary, V Vasiliou, Q Yan, K Nyhan… - Environment …, 2022 - Elsevier
Objective To summarize the application of non-targeted metabolomics in epidemiological
studies that assessed metabolite and metabolic pathway alterations associated with per-and …