The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

The ubiquitin proteasome system (UPS) is critically important for cellular homeostasis and
affects virtually all key functions in normal and neoplastic cells. Currently, a comprehensive …

The complexity of lung adenocarcinoma (LUAD) including many interacting biological
processes makes it difficult to find therapeutic biomarkers for treatment. Previous studies …

Circulating DNA (cirDNA) is a promising tool in translational medicine. However, studies of
cirDNA have neglected its association with proteins, despite ample evidence that this …

Background The molecular complexity of colorectal cancer poses a significant challenge to
the clinical implementation of accurate risk stratification. There is still an urgent need to find …

Background Esophageal cancer is a common malignant tumor of digestive tract with
esophageal squamous cell carcinoma (ESCC) being the main histological subtype. This …

Abstract Background Nuclear pore complexes (NPCs) are sophisticated and dynamic
protein structures that straddle the nuclear envelope and act as gatekeepers for transporting …

Activation of HER2/ErbB2 coincides with escape from ductal carcinoma in situ (DCIS)
premalignancy and disrupts 3D organization of cultured breast-epithelial spheroids. The 3D …

The broodiness traits of domestic geese are a bottleneck that prevents the rapid
development of the goose industry. To reduce the broodiness of the Zhedong goose and …

Nucleoporins (NUPs) are components of the nuclear pore complex (NPC) that participate in
the nucleocytoplasmic transport of macromolecules as well as in many essential processes …