Alzheimer's disease (AD) is a neurodegenerative disorder with devastating symptoms,
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence in
the brain of extracellular amyloid-protein (A) and intracellular neurofibrillary tangles …

The great potential for NMDA receptor modulators as druggable targets in
neurodegenerative disorders has been met with limited success. Considered one of the rare …

Memantine, a non-competitive NMDA receptor antagonist possessing neuroprotective
properties, belongs to the small group of drugs which have been approved for the treatment …

Abstract Clinical trial failures (> 99%) in Alzheimer's disease are in stark contrast to positive
efficacy data in animals. We evaluated the correlation between animal and clinical efficacy …

Abstract The Ca2+ hypothesis for Alzheimer's disease (AD) conceives Ca2+
dyshomeostasis as a common mechanism of AD; the cause of Ca2+ dysregulation …

In 2013, we discovered that the entitled “calcium paradox” phenomenon, which means a
paradoxical sympathetic hyperactivity produced by l-type Ca 2+ channel blockers (CCBs) …

Currently, of the few accessible symptomatic therapies for Alzheimer's disease (AD),
memantine is the only N-methyl-d-aspartate receptor (NMDAR) blocker approved by the …

Amyloid-β (Aβ) plaque formation, neuronal cell death, and cognitive impairment are the
unique symptoms of Alzheimer's disease (AD). No single step remedy is available to treat …

Scope The consumption of green tea is considered to be associated with a lower incidence
of neurodegenerative diseases. In the present study, it is investigated the role of amyloid …