[HTML][HTML] Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers

J Jin, Y Xie, JS Zhang, JQ Wang, SJ Dai, W He… - Drug Resistance …, 2023 - Elsevier
Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

Fisetin, a potent anticancer flavonol exhibiting cytotoxic activity against neoplastic malignant cells and cancerous conditions: a scoping, comprehensive review

R Kubina, K Krzykawski, A Kabała-Dzik, RD Wojtyczka… - Nutrients, 2022 - mdpi.com
Diet plays a crucial role in homeostasis maintenance. Plants and spices containing
flavonoids have been widely used in traditional medicine for thousands of years. Flavonols …

Flavonoids synergistically enhance the anti-glioblastoma effects of chemotherapeutic drugs

K Zhai, A Mazurakova, L Koklesova, P Kubatka… - Biomolecules, 2021 - mdpi.com
Flavonoids are polyphenolic plant secondary metabolites with pleiotropic biological
properties, including anti-cancer activities. These natural compounds have potential utility in …

Glutathione and neodiosmin feedback sustain plant immunity

C Lu, Y Jiang, Y Yue, Y Sui, M Hao… - Journal of …, 2023 - academic.oup.com
Plants have evolved a two-layer immune system comprising pattern-triggered immunity (PTI)
and effector-triggered immunity (ETI) that is activated in response to pathogen invasion …

[HTML][HTML] Natural flavone hispidulin protects mice from Staphylococcus aureus pneumonia by inhibition of α-hemolysin production via targeting AgrAC

X Ren, X Guo, C Liu, S Jing, T Wang, L Wang… - Microbiological …, 2022 - Elsevier
The emergence of drug-resistant Staphylococcus aureus (S. aureus) has limited drug
options for the clinical treatment of S. aureus infections. Considering recent reports …

Phytochemicals for the prevention and treatment of renal cell carcinoma: preclinical and clinical evidence and molecular mechanisms

EM Bajalia, FB Azzouz, DA Chism, DM Giansiracusa… - Cancers, 2022 - mdpi.com
Simple Summary Renal cell carcinoma (RCC) is the most frequently diagnosed kidney
cancer. Once RCC metastasizes, successful treatment is difficult to achieve. There is an …

Stevia Genus: Phytochemistry and Biological Activities Update

J Borgo, LC Laurella, F Martini, CAN Catalán… - Molecules, 2021 - mdpi.com
The Stevia genus (Asteraceae) comprises around 230 species, distributed from the southern
United States to the South American Andean region. Stevia rebaudiana, a Paraguayan herb …

Neuroimmunomodulatory properties of flavonoids and derivates: a potential action as adjuvants for the treatment of glioblastoma

RP do Nascimento, BL Dos Santos, JAO Amparo… - Pharmaceutics, 2022 - mdpi.com
Glioblastomas (GBMs) are tumors that have a high ability to migrate, invade and proliferate
in the healthy tissue, what greatly impairs their treatment. These characteristics are …

Phytochemical Analysis and Anti-Cancer Properties of Extracts of Centaurea castriferrei Borbás & Waisb Genus of Centaurea L

J Kubik, Ł Waszak, G Adamczuk, E Humeniuk, M Iwan… - Molecules, 2022 - mdpi.com
The Centaurea L.(Asteraceae) genus includes many plant species with therapeutic
properties. Centaurea castriferrei Borbás & Waisb is one of the least known and least …

Phytochemicals for the prevention and treatment of pancreatic cancer: Current progress and future prospects

N Casarcia, P Rogers, E Guld, S Iyer… - British Journal of …, 2023 - Wiley Online Library
Pancreatic cancer is the third leading cause of cancer‐related deaths in the United States,
owing to its aggressive nature and suboptimal treatment options, emphasizing the need for …