The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

Neuronal cell death in the central nervous system has always been a challenging process to
decipher. In normal physiological conditions, neuronal cell death is restricted in the adult …

Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …

Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which
severely impacts on the global economic development and healthcare system. Though AD …

The purpose of this study was to use serial imaging to gain insight into the sequence of
pathologic events in Alzheimer's disease, and the clinical features associated with this …

Lower brain glucose metabolism is present before the onset of clinically measurable
cognitive decline in two groups of people at risk of Alzheimer's disease---carriers of …

The role of brain cholesterol metabolism in Alzheimer's disease (AD) remains unclear.
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …

Diabetes and hyperinsulinemia may be risk factors for Alzheimer's disease (AD). We
conducted a pilot study of metformin, a medication efficacious in treating and preventing …

Alzheimer's disease (AD), including its mild cognitive impairment (MCI) phase that may or
may not progress into the AD, is the most ordinary form of dementia. It is extremely important …

Considerable evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the progression of Alzheimer's disease (AD). We examined the ability of the …