Regulation of amino acid's biosynthetic pathway is of significant importance to maintain
homeostasis and cell functions. Amino acids regulate their biosynthetic pathway by end …

Abstract Strategy, Management and Health Policy Enabling Technology, Genomics,
Proteomics Preclinical Research Preclinical Development Toxicology, Formulation Drug …

Flippases are enzymes that translocate phosphatidylserine (PtdSer) and
phosphatidylethanolamine (PtdEtn) from the outer to the inner leaflet in the lipid bilayer of …

β-Caryophyllene is a plant-derived bicyclic sesquiterpene with multiple biological functions.
β-Caryophyllene production by engineered Saccharomyces cerevisiae represents a …

L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL).
The main prerequisite for clinical efficacy of L-asparaginases is micromolar KM for …

Biotransformation with the help of enzymes can greatly improve the rate and
stereospecificity of reactions in organic chemistry. However, the use of organic solvents and …

Redesigning protein-protein interfaces is an important tool for developing therapeutic
strategies. Interfaces can be redesigned by in silico screening, which allows for efficient …

XynCDBFV from Neocallimastix patriciarum is among the most effective xylanases and
holds great potentials in a wide variety of industrial applications. In the present study …

Microbial transglutaminase (mTGase) is commonly known in the food industry as meat glue
due to its incredible ability to “glue” meat proteins together. Aside from being widely …

Iterative saturation mutagenesis (ISM) in combination with reduced amino acid alphabets
has been shown to be an efficient method for directed evolution. In order to minimize the …