The central nervous system (CNS) is vulnerable to pathologic processes that lead to the
development of neurodegenerative disorders like Alzheimer's, Parkinson's and Huntington's …

Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …

Abstract Opuntia ficus-indica (L.) Mill.(OFI), also known as Indian fig Opuntia or prickly pear,
is a member of the family Cactaceae that produces edible, nutritionally rich sweet fruits. It …

The gut microbiota has been demonstrated to play a critical role in maintaining cognitive
function via the gut-brain axis, which may be related to the parasympathetic nervous system …

Nasal administration has been demonstrated as an effective alternative for drug delivery to
central nervous system (CNS), especially for use in neurodegenerative diseases. Donepezil …

A donepezil hydrochloride (DPZ)-reinforced cellulose nanocrystal (CNC) hydrogel structure
with pH control was developed for sustained drug delivery through subcutaneous injection …

Neurological complications that occur in SARS-CoV-2 infection, such as olfactory
dysfunction, brain inflammation, malaise, and depressive symptoms, are thought to …

The cholinesterase enzymes play a vital role in maintaining balanced levels of the
neurotransmitter acetylcholine in the central nervous system. However, the overexpression …

The Corpus Callosum (CC) is an important structure that includes the majority of fibers
connecting the two brain hemispheres. Several neurodegenerative diseases may alter CC …

Background: A potent acetylcholinesterase inhibitor, donepezil is a cognitive enhancer
clinically used to treat neurodegenerative diseases. However, its complete pharmacological …