The additive memory and healthspan enhancement effects by the combined treatment of mature silkworm powders and Korean angelica extracts

P Nguyen, KY Kim, AY Kim, SK Kang… - Journal of …, 2021 - Elsevier
Abstracts Ethnopharmacological relevance Silkworm (Bombyx mori) and Korean angelica
(KoAg; Angelica gigas Nakai) have been widely used as traditional oriental medicines in …

ADME/PK Insights of Crocetin: A Molecule Having an Unusual Chemical Structure with Druglike Features

D Manhas, S Dhiman, H Kour, D Kour, K Sharma… - ACS …, 2024 - ACS Publications
Crocetin is a promising phyto-based molecule to treat Alzheimer's disease (AD). The
chemical structure of crocetin is incongruent with various standard structural features of CNS …

The Effect of Ethanol Extract from Mesua ferrea Linn Flower on Alzheimer's Disease and Its Underlying Mechanism

K Plekratoke, C Boonyarat, O Monthakantirat… - Current Issues in …, 2023 - mdpi.com
The effects of Mesua ferrea Linn flower (MFE) extract on the pathogenic cascade of
Alzheimer's disease (AD) were determined by an in vitro and cell culture model in the search …

Exploring Cannabinoids with Enhanced Binding Affinity for Targeting the Expanded Endocannabinoid System: A Promising Therapeutic Strategy for Alzheimer's …

GD Stanciu, DC Ababei, C Solcan, CM Uritu… - Pharmaceuticals, 2024 - mdpi.com
Despite decades of rigorous research and numerous clinical trials, Alzheimer's disease (AD)
stands as a notable healthcare challenge of this century, with effective therapeutic solutions …

A molecular container providing supramolecular protection against acetylcholine hydrolysis

YL Lu, J Su, JW Li, WR Xu - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
Alzheimer's disease (AD) is characterized by cognitive decline, often attributed to the
deficiency of acetylcholine, which can undergo hydrolysis by acetylcholinesterase (AChE) …

Circadian ABCG2 Expression Influences the Brain Uptake of Donepezil across the Blood–Cerebrospinal Fluid Barrier

A Furtado, AC Duarte, AR Costa, I Gonçalves… - International Journal of …, 2024 - mdpi.com
Donepezil (DNPZ) is a cholinesterase inhibitor used for the management of Alzheimer's
disease (AD) and is dependent on membrane transporters such as ABCG2 to actively cross …

Hydrolase‐Treated Royal Jelly Attenuates H2O2‐ and Glutamate‐Induced SH‐SY5Y Cell Damage and Promotes Cognitive Enhancement in a Rat Model of …

N Sirinupong, W Chansuwan… - International Journal of …, 2021 - Wiley Online Library
Vascular dementia (VaD) is the second most common type of dementia following
Alzheimer's disease, but the therapeutic efficacy is still not effective. This makes the …

[HTML][HTML] Anxiolytic, Antidepression, and Memory-Enhancing Effects of the Novel Instant Soup RJ6601 in the Middle-Aged of Female Rats

R Chaisanam, J Wattanathorn, W Thukham-Mee… - Foods, 2024 - mdpi.com
Due to the health benefits of polyphenols and dietary fiber in combating mental disorders,
we hypothesized that a polyphenol-and dietary fiber-enriched soup (RJ6601) would improve …

Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats

M Li, C Zheng, T Kawada, M Inagaki, K Uemura… - The Journal of …, 2020 - Springer
Oral administration of donepezil, a centrally acting acetylcholinesterase inhibitor, improves
the survival of rats with chronic heart failure (CHF). The mechanisms of cardioprotective …

Effect of resveratrol and combination of resveratrol and donepezil on the expression of microglial cells and astrocytes in Wistar albino rats of colchicine-induced …

YL Rao, B Ganaraja, PK Suresh, T Joy, SD Ullal… - 3 Biotech, 2023 - Springer
Aim The goal was to evaluate the effect of resveratrol (RS) and combination therapy of RS
and donepezil (DPZ), on the numerical expression of microglial cells and astrocytes, in the …