HLA-G: an immune checkpoint molecule

ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

[HTML][HTML] Human leukocyte antigen (HLA) and immune regulation: how do classical and non-classical HLA alleles modulate immune response to human …

NB Crux, S Elahi - Frontiers in immunology, 2017 - frontiersin.org
The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …

[HTML][HTML] HLA-G: too much or too little? Role in cancer and autoimmune disease

JM Martín-Villa, C Vaquero-Yuste… - Frontiers in …, 2022 - frontiersin.org
HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was
initially described at the maternal-fetal interface, and it was later found that this molecule …

Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention?

L Amiot, S Ferrone, H Grosse-Wilde… - Cellular and Molecular Life …, 2011 - Springer
Although the expression of the non-classical HLA class I molecule HLA-G was first reported
to be restricted to the fetal–maternal interface on the extravillous cytotrophoblasts, the …

HLA associations and HLA sharing in recurrent miscarriage: a systematic review and meta-analysis

T Meuleman, LELO Lashley, OM Dekkers… - Human immunology, 2015 - Elsevier
Problem The aim of this meta-analysis was to evaluate whether specific maternal HLA
alleles and HLA sharing of couples are associated with the occurrence of recurrent …

[HTML][HTML] Regulatory T cells in pregnancy: it is not all about FoxP3

J Krop, S Heidt, FHJ Claas, M Eikmans - Frontiers in immunology, 2020 - frontiersin.org
In pregnancy, the semi-allogeneic fetus needs to be tolerated by the mother's immune
system. Regulatory T cells (Tregs) play a prominent role in this process. Novel technologies …

HLA and tumour immunology: immune escape, immunotherapy and immune-related adverse events

N Jiang, Y Yu, D Wu, S Wang, Y Fang, H Miao… - Journal of cancer …, 2023 - Springer
Purpose As molecules responsible for presenting antigens to T lymphocytes, leukocytes
antigens (HLAs) play a vital role in cancer immunology. This review aims to provide current …

[HTML][HTML] Perspective of HLA-G induced immunosuppression in SARS-CoV-2 infection

A Lin, WH Yan - Frontiers in immunology, 2021 - frontiersin.org
COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), has threatened public health worldwide. Host antiviral immune responses are …

[HTML][HTML] HLA class Ib molecules and immune cells in pregnancy and preeclampsia

S Djurisic, TVF Hviid - Frontiers in immunology, 2014 - frontiersin.org
Despite decades of research, the highly prevalent pregnancy complication
preeclampsia,“the disease of theories,” has remained an enigma. Indeed, the etiology of …

[HTML][HTML] Controlling the immunological crosstalk during conception and pregnancy: HLA-G in reproduction

L Lynge Nilsson, S Djurisic, TVF Hviid - Frontiers in immunology, 2014 - frontiersin.org
In several years after its discovery in the placenta, the human leukocyte antigen (HLA) class
Ib protein, HLA-G, was not given much attention, nor was it assigned great importance. As …