[HTML][HTML] Metagenomics-enabled microbial surveillance
KKK Ko, KR Chng, N Nagarajan - Nature Microbiology, 2022 - nature.com
Lessons learnt from the COVID-19 pandemic include increased awareness of the potential
for zoonoses and emerging infectious diseases that can adversely affect human health …
for zoonoses and emerging infectious diseases that can adversely affect human health …
Agnostic sequencing for detection of viral pathogens
NPG Gauthier, SD Chorlton, M Krajden… - Clinical microbiology …, 2023 - Am Soc Microbiol
The advent of next-generation sequencing (NGS) technologies has expanded our ability to
detect and analyze microbial genomes and has yielded novel molecular approaches for …
detect and analyze microbial genomes and has yielded novel molecular approaches for …
[HTML][HTML] Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
SARS-CoV-2 infection is characterized by peak viral load in the upper airway prior to or at
the time of symptom onset, an unusual feature that has enabled widespread transmission of …
the time of symptom onset, an unusual feature that has enabled widespread transmission of …
[HTML][HTML] Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults
We carried out integrated host and pathogen metagenomic RNA and DNA next generation
sequencing (mNGS) of whole blood (n= 221) and plasma (n= 138) from critically ill patients …
sequencing (mNGS) of whole blood (n= 221) and plasma (n= 138) from critically ill patients …
[HTML][HTML] Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics
The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well
understood, and a common cause of meningitis in this region, Mycobacterium tuberculosis …
understood, and a common cause of meningitis in this region, Mycobacterium tuberculosis …
[HTML][HTML] Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
The IMPACC cohort, composed of> 1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
Discovery and genomic characterization of a novel Henipavirus, Angavokely virus, from fruit bats in Madagascar
ABSTRACT The genus Henipavirus (family Paramyxoviridae) currently comprises seven
viruses, four of which have demonstrated prior evidence of zoonotic capacity. These include …
viruses, four of which have demonstrated prior evidence of zoonotic capacity. These include …
[HTML][HTML] Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
Background Antimicrobial resistance (AMR) is rising at an alarming rate and complicating
the management of infectious diseases including lower respiratory tract infections (LRTI) …
the management of infectious diseases including lower respiratory tract infections (LRTI) …
Discovering disease-causing pathogens in resource-scarce Southeast Asia using a global metagenomic pathogen monitoring system
Understanding the regional pathogen landscape and surveillance of emerging pathogens is
key to mitigating epidemics. Challenges lie in resource-scarce settings, where outbreaks are …
key to mitigating epidemics. Challenges lie in resource-scarce settings, where outbreaks are …
[HTML][HTML] Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay
Mosquitoes are major infectious disease-carrying vectors. Assessment of current and future
risks associated with the mosquito population requires knowledge of the full repertoire of …
risks associated with the mosquito population requires knowledge of the full repertoire of …