Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory
responses across the immune landscape. These regulatory responses help to protect …

CD4+ Th cell differentiation is crucial for protecting against blood-stage Plasmodium
parasites, the causative agents of malaria. It has been known for decades that more than …

Objectives To determine whether sequestration of parasitized red blood cells differs
between children with uncomplicated and severe Plasmodium falciparum malaria. Methods …

To investigate the role of CD4+ CD25+ Foxp3+ regulatory T (Treg) cells in blood-stage
malaria, we compared Plasmodium chabaudi AS infection in wild-type (WT) C57BL/6 and …

A century of conceptual and technological advances in infectious disease research has
changed the face of medicine. However, there remains a lack of effective interventions and a …

The inhibition of TNF with therapeutic monoclonal antibodies or antibody/receptor fusion
proteins in rheumatoid arthritis still constitutes the benchmark for a successful intervention in …

The development of highly effective malaria vaccines and improvement of drug-treatment
protocols to boost antiparasitic immunity are critical for malaria elimination. However, the …

CD4+ T cells that produce IFN-γ are the source of host-protective IL-10 during primary
infection with a number of different pathogens, including Plasmodium spp. The fate of these …

Background A mother's infection with placental malaria (PM) can affect her child's
susceptibility to malaria, although the mechanism remains unclear. The fetus acquires a …

Abstract Background Asymptomatic Plasmodium infections are characterized by the
absence of clinical disease and the ability to restrict parasite replication. Increasing levels of …