GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
Abstract Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily
whose expression is increased in response to cellular stress and disease as well as by …
whose expression is increased in response to cellular stress and disease as well as by …
The GDF15-GFRAL pathway in health and metabolic disease: friend or foe?
GDF15 is a cell activation and stress response cytokine of the glial cell line–derived
neurotrophic factor family within the TGF-β superfamily. It acts through a recently identified …
neurotrophic factor family within the TGF-β superfamily. It acts through a recently identified …
Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia
Growth differentiation factor 15 or macrophage inhibitory cytokine-1 (GDF15/MIC-1) is a
divergent member of the transforming growth factor β superfamily and has a diverse …
divergent member of the transforming growth factor β superfamily and has a diverse …
Overview of growth differentiation factor 15 in metabolic syndrome
Growth and differentiation factor 15 (GDF15) is a member of the transforming growth factor‐β
(TGF‐β) superfamily. GDF15 has been linked with several metabolic syndrome pathologies …
(TGF‐β) superfamily. GDF15 has been linked with several metabolic syndrome pathologies …
GDF15 mediates the effect of skeletal muscle contraction on glucose-stimulated insulin secretion
H Zhang, A Mulya, S Nieuwoudt, B Vandanmagsar… - Diabetes, 2023 - Am Diabetes Assoc
Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto
unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act …
unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act …
The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice
Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) plays a role in various
diseases. Here, the anti-diabetic effects of NAG-1 were evaluated using a high-fat …
diseases. Here, the anti-diabetic effects of NAG-1 were evaluated using a high-fat …
GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans
P Plomgaard, JS Hansen, LK Townsend… - Frontiers in …, 2022 - frontiersin.org
Objective Growth differentiation factor (GDF)-15 is implicated in regulation of metabolism
and circulating GDF15 increases in response to exercise. The source and regulation of the …
and circulating GDF15 increases in response to exercise. The source and regulation of the …
The clinical impact of growth differentiation factor-15 in heart disease: A 2019 update
M Arkoumani, N Papadopoulou-Marketou… - Critical Reviews in …, 2020 - Taylor & Francis
Abstract Growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory
cytokine-1 (MIC-1) or non-steroidal anti-inflammatory drug-activated gene (NAG-1) has been …
cytokine-1 (MIC-1) or non-steroidal anti-inflammatory drug-activated gene (NAG-1) has been …
[HTML][HTML] Growth differentiation factor-15, a novel systemic biomarker of oxidative stress, inflammation, and cellular aging: Potential role in cardiovascular diseases
AM di Candia, DX de Avila, GR Moreira… - American Heart Journal …, 2021 - Elsevier
Abstract Growth differentiation factor-15 (GDF-15) is a cytokine upregulated in multiple
pathological conditions where oxidative stress, endothelial dysfunction, tissue aging, and …
pathological conditions where oxidative stress, endothelial dysfunction, tissue aging, and …
Growth‐differentiation‐factor 15 levels in obese and healthy pregnancies: relation to insulin resistance and insulin secretory function
U Andersson‐Hall, L Joelsson, P Svedin… - Clinical …, 2021 - Wiley Online Library
Abstract Objective/Aim Growth‐differentiation‐factor 15 (GDF15) has been suggested to
improve or protect beta cell function. During pregnancy, beta cell numbers and function …
improve or protect beta cell function. During pregnancy, beta cell numbers and function …