Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection

M Lyu, CL Yan, HX Liu, TY Wang, XH Shi, JP Liu… - Scientific Reports, 2017 - nature.com
Although Danhong injection (DHI) is the most widely prescribed Chinese medicine for both
stroke and coronary artery disease (CAD), its underlying common molecular mechanisms …

Strategies for quality control of Chinese medicines

SP Li, J Zhao, B Yang - Journal of Pharmaceutical and Biomedical Analysis, 2011 - Elsevier
Chinese medicines (CM) have been attracting interest and acceptance in many countries.
Quality control is vital for ensuring the safety and efficacy of CM. Usually, CM are used as …

Bioactive phytochemicals from shoots and roots of Salvia species

AR Jassbi, S Zare, O Firuzi, J Xiao - Phytochemistry reviews, 2016 - Springer
The plants of the genus Salvia L. are important medicinal herbs of the Lamiaceae family and
some of them such as S. officinalis (sage), S. miltiorrhiza (red sage, Danshen) and S. sclarea …

Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway

F Maione, V De Feo, E Caiazzo, L De Martino… - Journal of …, 2014 - Elsevier
Ethnopharmacological relevance The roots of Salvia milthorriza Bunge (Lamiaceae) known
as “Danshen”, are used in Traditional Chinese Medicine as a remedy for activating blood …

Research and development of natural product tanshinone I: pharmacology, total synthesis, and structure modifications

X Huang, L Jin, H Deng, D Wu, Q Shen… - Frontiers in …, 2022 - frontiersin.org
Salvia miltiorrhiza (S. miltiorrhiza), which has been used for thousands of years to treat
cardiovascular diseases, is a well-known Chinese medicinal plant. The fat-soluble …

Tanshinone IIA inhibits HIF-1α and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway

G Li, C Shan, L Liu, T Zhou, J Zhou, X Hu, Y Chen… - PLoS …, 2015 - journals.plos.org
Hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) play
important roles in angiogenesis and tumor growth. Tanshinone IIA (T2A) is a novel …

The AP2/ERF transcription factor SmERF128 positively regulates diterpenoid biosynthesis in Salvia miltiorrhiza

Y Zhang, A Ji, Z Xu, H Luo, J Song - Plant molecular biology, 2019 - Springer
Key message The novel AP2/ERF transcription factor SmERF128 positively regulates
diterpenoid tanshinone biosynthesis by activating the expression of SmCPS1, SmKSL1, and …

Genome-wide characterization and comparative analysis of R2R3-MYB transcription factors shows the complexity of MYB-associated regulatory networks in Salvia …

C Li, S Lu - BMC genomics, 2014 - Springer
Background MYB is the largest plant transcription factor gene family playing vital roles in
plant growth and development. However, it has not been systematically studied in Salvia …

Recent insights into the biological activities and drug delivery systems of tanshinones

Y Cai, W Zhang, Z Chen, Z Shi, C He… - International Journal of …, 2016 - Taylor & Francis
Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal
herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the …

Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine

T Lu, J Yang, X Gao, P Chen, F Du, Y Sun… - Drug Metabolism and …, 2008 - ASPET
Cardiotonic pills are a type of cardiovascular herbal medicine. To identify suitable
pharmacokinetic (PK) marker (s) for indicating systemic exposure to cardiotonic pills, we …