Recent insights into the biological activities and drug delivery systems of tanshinones

Y Cai, W Zhang, Z Chen, Z Shi, C He… - International Journal of …, 2016 - Taylor & Francis
Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal
herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the …

Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine

T Lu, J Yang, X Gao, P Chen, F Du, Y Sun… - Drug Metabolism and …, 2008 - ASPET
Cardiotonic pills are a type of cardiovascular herbal medicine. To identify suitable
pharmacokinetic (PK) marker (s) for indicating systemic exposure to cardiotonic pills, we …

[PDF][PDF] Advancements in the production of secondary metabolites

V Varma - Journal of Natural Products, 2010 - researchgate.net
Plant cell culture systems represent a potential renewable source of valuable medicinal
compounds, flavours, fragrances, and colorants, which cannot be produced by microbial …

Investigation of Danshen and related medicinal plants in China

MH Li, JM Chen, Y Peng, Q Wu, PG Xiao - Journal of ethnopharmacology, 2008 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: In China, over 20 Salvia species have been
used as Danshen in traditional folk medicine for the treatment of coronary heart diseases …

Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA …

M Shi, X Luo, G Ju, X Yu, X Hao, Q Huang… - Functional & integrative …, 2014 - Springer
Tanshinone is widely used for treatment of cardio-cerebrovascular diseases with increasing
demand. Herein, key enzyme genes SmHMGR (3-hydroxy-3-methylglutaryl CoA reductase) …

[HTML][HTML] The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV

S Tao, R Justiniano, DD Zhang, GT Wondrak - Redox Biology, 2013 - Elsevier
Exposure to solar ultraviolet (UV) radiation is a causative factor in skin photocarcinogenesis
and photoaging, and an urgent need exists for improved strategies for skin photoprotection …

Fate of antibiotic resistance genes and mobile genetic elements during anaerobic co-digestion of Chinese medicinal herbal residues and swine manure

L Zhang, J Gu, X Wang, R Zhang, X Tuo, A Guo… - Bioresource …, 2018 - Elsevier
Swine manure is an important reservoir for antibiotic resistance genes (ARGs) but anaerobic
co-digestion (AcoD) can potentially reduce the abundance of these ARGs. However, few …

丹参及其主要成分保肝作用的研究进展

袁媛, 吴芹, 石京山, 陈修平, 丹参 - 中国中药杂志, 2015 - cqvip.com
丹参是临床最常用的中药之一, 丹参的药效物质基础主要包括脂溶性的丹参酮类和水溶性的丹酚
酸类. 丹参具有" 祛瘀止痛, 活血通经, 清心除烦" 等传统功效. 现代药理学研究表明 …

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

VG D'Agostino, P Lal, B Mantelli, C Tiedje, C Zucal… - Scientific reports, 2015 - nature.com
Post-transcriptional regulation is an essential determinant of gene expression programs in
physiological and pathological conditions. HuR is a RNA-binding protein that orchestrates …

Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines

TKH Chang - The AAPS journal, 2009 - Springer
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are transcription
factors that control the expression of a broad array of genes involved not only in transcellular …